PPP1R14B

Protein phosphatase 1 regulatory subunit 14B is an enzyme that in humans is encoded by the PPP1R14B gene.[5][6][7]

PPP1R14B
Identifiers
Aliases	PPP1R14B, PHI-1, PLCB3N, PNG, SOM172, protein phosphatase 1 regulatory inhibitor subunit 14B
External IDs	OMIM: 601140 MGI: 107682 HomoloGene: 7483 GeneCards: PPP1R14B
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,244,479 bp[1] End 64,246,943 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,974,968 bp[2] End 6,977,324 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein phosphatase inhibitor activity • phosphatase inhibitor activity • protein phosphatase regulator activity • protein serine/threonine phosphatase inhibitor activity Cellular component • cytoplasm Biological process • regulation of phosphorylation • innate immune system • negative regulation of phosphoprotein phosphatase activity • GO:0048553 negative regulation of catalytic activity • regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26472	18938
Ensembl	ENSG00000173457	ENSMUSG00000056612
UniProt	Q96C90	Q62084
RefSeq (mRNA)	NM_138689	NM_008889
RefSeq (protein)	NP_619634	NP_032915
Location (UCSC)	Chr 11: 64.24 – 64.25 Mb	Chr 19: 6.97 – 6.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000173457 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056612 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lagercrantz J, Carson E, Larsson C, Nordenskjold M, Weber G (Mar 1997). "Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13". Genomics. 31 (3): 380–4. doi:10.1006/geno.1996.0063. PMID 8838322.
6. Eto M, Karginov A, Brautigan DL (Jan 2000). "A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes". Biochemistry. 38 (51): 16952–7. doi:10.1021/bi992030o. PMID 10606530.
7. "Entrez Gene: PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B".

Further reading

• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tountas NA, Mandell JW, Everett AD, Brautigan DL (2005). "Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells". Histochem. Cell Biol. 121 (4): 343–50. doi:10.1007/s00418-004-0642-8. PMID 15083373. S2CID 21262452.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tountas NA, Brautigan DL (2005). "Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein". J. Cell Sci. 117 (Pt 24): 5905–12. doi:10.1242/jcs.01506. PMID 15522888.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.