POLR1D

DNA-directed RNA polymerases I and III subunit RPAC2 is a protein that in humans is encoded by the POLR1D gene.[5][6][7]

POLR1D
Identifiers
Aliases	POLR1D, AC19, POLR1C, RPA16, RPA9, RPAC2, RPC16, RPO1-3, TCS2, polymerase (RNA) I subunit D, RNA polymerase I subunit D, RNA polymerase I and III subunit D
External IDs	OMIM: 613715 MGI: 108403 HomoloGene: 22239 GeneCards: POLR1D
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.2 Start 27,620,742 bp[1] End 27,744,237 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G3 Start 147,077,050 bp[2] End 147,111,597 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • protein dimerization activity • RNA polymerase III activity • DNA-directed 5'-3' RNA polymerase activity • GO:0001948 protein binding • RNA polymerase I activity Cellular component • cytosol • nucleoplasm • DNA-directed RNA polymerase I complex • DNA-directed RNA polymerase III complex • cell nucleus Biological process • termination of RNA polymerase I transcription • positive regulation of gene expression, epigenetic • transcription initiation from RNA polymerase I promoter • transcription, DNA-templated • transcription elongation from RNA polymerase I promoter • positive regulation of type I interferon production • transcription from RNA polymerase III promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51082	20018
Ensembl	ENSG00000186184	ENSMUSG00000029642
UniProt	P0DPB5	P97304
RefSeq (mRNA)	NM_001206559 NM_015972 NM_152705 NM_001374407	NM_009087 NM_181730
RefSeq (protein)	NP_001193488 NP_057056 NP_689918 NP_001361336	NP_033113 NP_859419
Location (UCSC)	Chr 13: 27.62 – 27.74 Mb	Chr 5: 147.08 – 147.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POLR1D has been shown to interact with POLR1C.[8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000186184 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029642 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
6. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Nov 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
7. "Entrez Gene: POLR1D polymerase (RNA) I polypeptide D, 16kDa".
8. Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M (Dec 1996). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III". The Journal of Biological Chemistry. 271 (51): 32881–5. doi:10.1074/jbc.271.51.32881. PMID 8955128.
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M (Dec 1996). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III". The Journal of Biological Chemistry. 271 (51): 32881–5. doi:10.1074/jbc.271.51.32881. PMID 8955128.
• Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T (Nov 2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science. 298 (5598): 1623–6. doi:10.1126/science.1076164. PMID 12446911.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jul 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Molecular and Cellular Biology. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.