PLXNB2

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.[5][6][7]

PLXNB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4E71
Identifiers
Aliases	PLXNB2, MM1, Nbla00445, PLEXB2, dJ402G11.3, plexin B2
External IDs	OMIM: 604293 MGI: 2154239 HomoloGene: 66630 GeneCards: PLXNB2
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.33 Start 50,274,979 bp[1] End 50,307,646 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E3|15 44.68 cM Start 89,155,549 bp[2] End 89,180,788 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • semaphorin receptor activity Cellular component • integral component of membrane • membrane • cell membrane • cell surface • extracellular exosome • integral component of plasma membrane • semaphorin receptor complex Biological process • regulation of protein phosphorylation • negative regulation of cell adhesion • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • positive regulation of axonogenesis • multicellular organism development • neural tube closure • brain development • regulation of cell shape • neuroblast proliferation • regulation of neuron migration • semaphorin-plexin signaling pathway • signal transduction • positive regulation of neuron projection development • homophilic cell adhesion via plasma membrane adhesion molecules • regulation of cell migration • semaphorin-plexin signaling pathway involved in axon guidance • excitatory synapse assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23654	140570
Ensembl	ENSG00000196576	ENSMUSG00000036606
UniProt	O15031	B2RXS4
RefSeq (mRNA)	NM_012401	NM_001159521 NM_001284506 NM_138749
RefSeq (protein)	NP_036533 NP_001363793 NP_001363794 NP_001363795 NP_001363796 NP_001363797 NP_001363798 NP_001363799 NP_001363800 NP_001363801 NP_001363802 NP_001363803 NP_001363804 NP_001363805 NP_001363806 NP_001363807 NP_001363808 NP_001363809 NP_001363810 NP_001363811 NP_001363812 NP_001363813 NP_001363814 NP_001363815	NP_001152993 NP_001271435 NP_620088
Location (UCSC)	Chr 22: 50.27 – 50.31 Mb	Chr 15: 89.16 – 89.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM][7]

Interactions

PLXNB2 has been shown to interact with ARHGEF11.[6][8]

References

1. GRCh38: Ensembl release 89: ENSG00000196576 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036606 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
6. Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J Biol Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
7. "Entrez Gene: PLXNB2 plexin B2".
8. Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.

Further reading

• Shinoura N, Shamraj OI, Hugenholz H, Zhu JG, McBlack P, Warnick R, Tew JJ, Wani MA, Menon AG (1995). "Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors". Cancer Lett. 89 (2): 215–21. doi:10.1016/0304-3835(95)03690-X. PMID 7889532.
• Trofatter JA, Long KR, Murrell JR, Stotler CJ, Gusella JF, Buckler AJ (1996). "An expression-independent catalog of genes from human chromosome 22". Genome Res. 5 (3): 214–24. doi:10.1101/gr.5.3.214. PMID 8593609.
• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
• Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.