PLXNB1

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.[5][6][7]

PLXNB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JPH, 2OS6, 2R2O, 2REX, 3HM6, 3OL2, 3SU8, 3SUA
Identifiers
Aliases	PLXNB1, PLEXIN-B1, PLXN5, SEP, plexin B1
External IDs	OMIM: 601053 MGI: 2154238 HomoloGene: 130508 GeneCards: PLXNB1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 48,403,854 bp[1] End 48,430,086 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 109,095,389 bp[2] End 109,119,917 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GTPase activating protein binding • semaphorin receptor activity • semaphorin receptor binding • GO:0001948 protein binding • transmembrane signaling receptor activity • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • signaling receptor activity Cellular component • integral component of membrane • membrane • cell membrane • semaphorin receptor complex • integral component of plasma membrane • extracellular region • intracellular Biological process • ossification involved in bone maturation • negative regulation of cell adhesion • neuron projection morphogenesis • GO:0007243 intracellular signal transduction • positive regulation of axonogenesis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • regulation of cell shape • axon extension • negative regulation of osteoblast proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • cell migration • regulation of cytoskeleton organization • semaphorin-plexin signaling pathway • signal transduction • semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • G-protein coupled receptor signaling pathway • regulation of cell migration • semaphorin-plexin signaling pathway involved in axon guidance • inhibitory synapse assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5364	235611
Ensembl	ENSG00000164050	ENSMUSG00000053646
UniProt	O43157	Q8CJH3
RefSeq (mRNA)	NM_001130082 NM_002673	NM_172775
RefSeq (protein)	NP_001123554 NP_002664	NP_766363
Location (UCSC)	Chr 3: 48.4 – 48.43 Mb	Chr 9: 109.1 – 109.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.[8] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.[9]

Interactions

PLXNB1 has been shown to interact with ARHGEF12,[10] Rnd1[11] and ARHGEF11.[10][11][12][13]

References

1. GRCh38: Ensembl release 89: ENSG00000164050 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053646 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A. 93 (2): 674–8. Bibcode:1996PNAS...93..674M. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
6. Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner". Proc Natl Acad Sci U S A. 97 (23): 12457–62. Bibcode:2000PNAS...9712457V. doi:10.1073/pnas.220421797. PMC 18785. PMID 11035813.
7. "Entrez Gene: PLXNB1 plexin B1".
8. Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 9, 2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Letters. 529 (2–3): 168–72. doi:10.1016/s0014-5793(02)03323-9. PMID 12372594. S2CID 26525009.
9. Basile JR, Afkhami T, Gutkind JS (Aug 2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway". Molecular and Cellular Biology. 25 (16): 6889–98. doi:10.1128/mcb.25.16.6889-6898.2005. PMC 1190270. PMID 16055703.
10. Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
11. Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
12. Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
13. Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608. S2CID 18981429.

• Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A and Keegan AD. "Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1". ImmunoHorizons, February 1, 2019, 3 (2) 71-87; DOI: https://doi.org/10.4049/immunohorizons.1800026}}

Further reading

• Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
• Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMC 186329. PMID 11937491.
• Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608. S2CID 18981429.
• Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
• Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL (2002). "The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12085–90. Bibcode:2002PNAS...9912085A. doi:10.1073/pnas.142433199. PMC 129402. PMID 12196628.
• Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L, Comoglio PM (2002). "The semaphorin 4D receptor controls invasive growth by coupling with Met". Nat. Cell Biol. 4 (9): 720–4. doi:10.1038/ncb843. PMID 12198496. S2CID 130071.
• Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
• Granziero L, Circosta P, Scielzo C, Frisaldi E, Stella S, Geuna M, Giordano S, Ghia P, Caligaris-Cappio F (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes". Blood. 101 (5): 1962–9. doi:10.1182/blood-2002-05-1339. PMID 12406905.
• Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
• Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun. 300 (4): 927–31. doi:10.1016/S0006-291X(02)02966-2. PMID 12559962.
• Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
• Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
• Swiercz JM, Kuner R, Offermanns S (2004). "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2". J. Cell Biol. 165 (6): 869–80. doi:10.1083/jcb.200312094. PMC 2172401. PMID 15210733.
• Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science. 305 (5685): 862–5. Bibcode:2004Sci...305..862O. doi:10.1126/science.1097545. PMID 15297673. S2CID 39544623.
• Conrotto P, Valdembri D, Corso S, Serini G, Tamagnone L, Comoglio PM, Bussolino F, Giordano S (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1". Blood. 105 (11): 4321–9. doi:10.1182/blood-2004-07-2885. PMID 15632204.

External links

• Overview of all the structural information available in the PDB for UniProt: O43157 (Plexin-B1) at the PDBe-KB.