PLSCR4

Phospholipid scramblase 4, also known as Ca²⁺-dependent phospholipid scramblase 4, is a protein that is encoded in humans by the PLSCR4 gene.[5][6]

PLSCR4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q5U
Identifiers
Aliases	PLSCR4, TRA1, phospholipid scramblase 4
External IDs	OMIM: 607612 MGI: 2143267 HomoloGene: 23217 GeneCards: PLSCR4
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q24 Start 146,192,335 bp[1] End 146,251,179 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 92,457,373 bp[2] End 92,492,456 bp[2]
Gene ontology Molecular function • SH3 domain binding • phospholipid scramblase activity • enzyme binding • calcium ion binding • CD4 receptor binding • GO:0001948 protein binding Cellular component • integral component of membrane • cell membrane • membrane Biological process • cellular response to lipopolysaccharide • phospholipid scrambling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57088	235527
Ensembl	ENSG00000114698	ENSMUSG00000032377
UniProt	Q9NRQ2	P58196
RefSeq (mRNA)	NM_001128304 NM_001128305 NM_001128306 NM_001177304 NM_020353	NM_178711
RefSeq (protein)	NP_001121776 NP_001121777 NP_001121778 NP_001170775 NP_065086	NP_848826
Location (UCSC)	Chr 3: 146.19 – 146.25 Mb	Chr 9: 92.46 – 92.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Scramblase

References

1. GRCh38: Ensembl release 89: ENSG00000114698 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032377 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: phospholipid scramblase 4".
6. Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (July 2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta. 1467 (1): 244–53. doi:10.1016/S0005-2736(00)00236-4. PMID 10930526.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shibata H, Suzuki H, Kakiuchi T, et al. (2008). "Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants". J. Biol. Chem. 283 (15): 9623–32. doi:10.1074/jbc.M800717200. PMID 18256029.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sahu SK, Aradhyam GK, Gummadi SN (2009). "Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell". Biochim. Biophys. Acta. 1790 (10): 1274–81. doi:10.1016/j.bbagen.2009.06.008. PMID 19540310.
• Py B, Basmaciogullari S, Bouchet J, et al. (2009). "The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane". PLOS ONE. 4 (3): e5006. doi:10.1371/journal.pone.0005006. PMC 2659420. PMID 19333378.