PLSCR1

Phospholipid scramblase 1 is an enzyme that in humans is encoded by the PLSCR1 gene.[5][6]

PLSCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y2A
Identifiers
Aliases	PLSCR1, MMTRA1B, phospholipid scramblase 1
External IDs	OMIM: 604170 MGI: 893575 HomoloGene: 41418 GeneCards: PLSCR1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q24 Start 146,515,180 bp[1] End 146,544,856 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 92,249,750 bp[2] End 92,272,278 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phospholipid scramblase activity • DNA binding • calcium ion binding • CD4 receptor binding • SH3 domain binding • epidermal growth factor receptor binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948 protein binding • enzyme binding Cellular component • integral component of membrane • cytosol • Golgi apparatus • membrane • extracellular matrix • cell membrane • integral component of plasma membrane • nucleolus • membrane raft • extracellular exosome • cell nucleus • cytoplasm • perinuclear region of cytoplasm • collagen-containing extracellular matrix Biological process • phosphatidylserine biosynthetic process • regulation of mast cell activation • phospholipid scrambling • positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity • response to interferon-beta • regulation of Fc receptor mediated stimulatory signaling pathway • platelet activation • negative regulation of viral genome replication • positive regulation of gene expression • defense response to virus • acute-phase response • positive regulation of innate immune response • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5359	22038
Ensembl	ENSG00000188313	ENSMUSG00000032369
UniProt	O15162	Q9JJ00
RefSeq (mRNA)	NM_021105 NM_001363872 NM_001363874	NM_011636
RefSeq (protein)	NP_066928 NP_001350801 NP_001350803	NP_035766
Location (UCSC)	Chr 3: 146.52 – 146.54 Mb	Chr 9: 92.25 – 92.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PLSCR1 has been shown to interact with:

• CPSF6,[7]
• Epidermal growth factor receptor,[8]
• NEU4,[7]
• SHC1,[8][9]
• SLPI,[10] and
• TFG.[7]

See also

• Scramblase

References

1. GRCh38: Ensembl release 89: ENSG00000188313 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032369 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ (August 1997). "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids". J Biol Chem. 272 (29): 18240–4. doi:10.1074/jbc.272.29.18240. PMID 9218461.
6. "Entrez Gene: PLSCR1 phospholipid scramblase 1".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
8. Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ (May 2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry. 41 (20): 6338–45. doi:10.1021/bi025610l. PMID 12009895.
9. Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T (September 2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor". J. Biol. Chem. 278 (39): 37413–8. doi:10.1074/jbc.M306182200. PMID 12871937.
10. Tseng CC, Tseng CP (June 2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement". FEBS Lett. 475 (3): 232–6. doi:10.1016/s0014-5793(00)01700-2. PMID 10869562. S2CID 35688498.

Further reading

• Bassé F, Stout JG, Sims PJ, Wiedmer T (1996). "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid". J. Biol. Chem. 271 (29): 17205–10. doi:10.1074/jbc.271.29.17205. PMID 8663431.
• Zhou Q, Sims PJ, Wiedmer T (1998). "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids". Biochemistry. 37 (8): 2356–60. doi:10.1021/bi972625o. PMID 9485382.
• Zhao J, Zhou Q, Wiedmer T, Sims PJ (1998). "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids". Biochemistry. 37 (18): 6361–6. doi:10.1021/bi980218m. PMID 9572851.
• Kasukabe T, Kobayashi H, Kaneko Y, Okabe-Kado J, Honma Y (1998). "Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene". Biochem. Biophys. Res. Commun. 249 (2): 449–55. doi:10.1006/bbrc.1998.9190. PMID 9712717.
• Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ (2000). "Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha". Blood. 95 (8): 2593–9. doi:10.1182/blood.V95.8.2593. PMID 10753839.
• Frasch SC, Henson PM, Kailey JM, Richter DA, Janes MS, Fadok VA, Bratton DL (2000). "Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta". J. Biol. Chem. 275 (30): 23065–73. doi:10.1074/jbc.M003116200. PMID 10770950.
• Tseng CC, Tseng CP (2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement". FEBS Lett. 475 (3): 232–6. doi:10.1016/S0014-5793(00)01700-2. PMID 10869562. S2CID 35688498.
• Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta. 1467 (1): 244–53. doi:10.1016/S0005-2736(00)00236-4. PMID 10930526.
• Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ (2001). "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1". J. Biol. Chem. 276 (31): 28984–90. doi:10.1074/jbc.M102505200. PMID 11390389.
• Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ (2002). "Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1". Cancer Res. 62 (2): 397–402. PMID 11809687.
• Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ (2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry. 41 (20): 6338–45. doi:10.1021/bi025610l. PMID 12009895.
• Zhou Q, Zhao J, Wiedmer T, Sims PJ (2002). "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1". Blood. 99 (11): 4030–8. doi:10.1182/blood-2001-12-0271. PMID 12010804.
• Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
• Nakamaki T, Okabe-Kado J, Yamamoto-Yamaguchi Y, Hino Ki, Tomoyasu S, Honma Y, Kasukabe T (2002). "Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytes". Exp. Hematol. 30 (5): 421–9. doi:10.1016/S0301-472X(02)00779-8. PMID 12031648.
• Wiedmer T, Zhao J, Nanjundan M, Sims PJ (2003). "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane". Biochemistry. 42 (5): 1227–33. doi:10.1021/bi026679w. PMID 12564925.
• Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y (2003). "Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))". J. Biol. Chem. 278 (17): 15239–45. doi:10.1074/jbc.M208611200. PMID 12586838.
• Rami A, Sims J, Botez G, Winckler J (2003). "Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia". Neurochem. Int. 43 (1): 79–87. doi:10.1016/S0197-0186(02)00194-8. PMID 12605885. S2CID 44845123.
• Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T (2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor". J. Biol. Chem. 278 (39): 37413–8. doi:10.1074/jbc.M306182200. PMID 12871937.