PLAGL2

Zinc finger protein PLAGL2 is a protein that in humans is encoded by the PLAGL2 gene.[5][6][7]

PLAGL2
Identifiers
AliasesPLAGL2, ZNF900, PLAG1 like zinc finger 2
External IDsOMIM: 604866 MGI: 1933165 HomoloGene: 1994 GeneCards: PLAGL2
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.21Start32,192,504 bp[1]
End32,207,743 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5326

54711

Ensembl

ENSG00000126003

ENSMUSG00000051413

UniProt

Q9UPG8

Q925T4

RefSeq (mRNA)

NM_002657

NM_018807

RefSeq (protein)

NP_002648

NP_061277

Location (UCSC)Chr 20: 32.19 – 32.21 MbChr 2: 153.23 – 153.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein PLAGL2 is a zinc finger protein that recognizes DNA and/or RNA.[7]

The gene has seen in gliomas to suppress cellular differentiation and thus encourage cells to become more stem cell like. Such plasticity is seen in glioma cells, together with the ignorance to differentiation factors.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000126003 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000051413 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH (Mar 2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood. 105 (7): 2900–7. doi:10.1182/blood-2004-09-3630. PMID 15585652.
  6. Zheng G, Ning J, Yang YC (Oct 2007). "PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53". Biochem Biophys Res Commun. 364 (2): 344–50. doi:10.1016/j.bbrc.2007.10.003. PMC 2708094. PMID 17950244.
  7. "Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2".
  8. Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA (May 2010). "PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma". Cancer Cell. 17 (5): 497–509. doi:10.1016/j.ccr.2010.03.020. PMC 2900858. PMID 20478531.

Further reading


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