PLA2G4B

Phospholipase A2, group IVB (cytosolic), also known as PLA2G4B, is a human gene.[3]

JMJD7-PLA2G4B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1BCI, 1CJY, 1RLW
Identifiers
Aliases	JMJD7-PLA2G4B, HsT16992, cPLA2-beta, PLA2G4B, JMJD7-PLA2G4B readthrough
External IDs	HomoloGene: 130533 GeneCards: JMJD7-PLA2G4B
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 41,828,095 bp[1] End 41,848,155 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • phospholipase activity • calcium-dependent phospholipase A2 activity • metal ion binding • calcium-dependent phospholipid binding • hydrolase activity • phospholipase A2 activity • phospholipase A1 activity • lysophospholipase activity • phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) • phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) Cellular component • cytoplasm • cytosol • endosome • early endosome membrane • membrane • mitochondrial membranes • extracellular region • mitochondrion • mitochondrial inner membrane Biological process • phosphatidic acid biosynthetic process • phosphatidylserine acyl-chain remodeling • phosphatidylethanolamine acyl-chain remodeling • glycerophospholipid catabolic process • lipid metabolism • lipid catabolic process • IRE1-mediated unfolded protein response • birth • phosphatidylglycerol acyl-chain remodeling • phospholipid catabolic process • phospholipid metabolic process • metabolism • inflammatory response • arachidonic acid metabolic process • phosphatidylcholine acyl-chain remodeling • calcium-mediated signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8681	n/a
Ensembl	ENSG00000168970	n/a
UniProt	P0C869	n/a
RefSeq (mRNA)	NM_001198588 NM_005090	n/a
RefSeq (protein)	NP_001185517 NP_005081	n/a
Location (UCSC)	Chr 15: 41.83 – 41.85 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000168970 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: PLA2G4B phospholipase A2, group IVB (cytosolic)".

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
• Underwood KW, Song C, Kriz RW, et al. (1998). "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2". J. Biol. Chem. 273 (34): 21926–32. doi:10.1074/jbc.273.34.21926. PMID 9705332.
• Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999). "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 274 (13): 8823–31. doi:10.1074/jbc.274.13.8823. PMID 10085124.
• Song C, Chang XJ, Bean KM, et al. (1999). "Molecular characterization of cytosolic phospholipase A2-beta". J. Biol. Chem. 274 (24): 17063–7. doi:10.1074/jbc.274.24.17063. PMID 10358058.
• Degousee N, Ghomashchi F, Stefanski E, et al. (2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis". J. Biol. Chem. 277 (7): 5061–73. doi:10.1074/jbc.M109083200. PMID 11741884.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ghosh M, Loper R, Gelb MH, Leslie CC (2006). "Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes". J. Biol. Chem. 281 (24): 16615–24. doi:10.1074/jbc.M601770200. PMID 16617059.