PIR (gene)

Pirin is a protein that in humans is encoded by the PIR gene.[5][6]

PIR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ERO, 4EWD, 4GUL, 1J1L, 4EWA, 4HLT, 3ACL, 4EWE
Identifiers
Aliases	PIR, pirin
External IDs	OMIM: 300931 MGI: 1916906 HomoloGene: 2717 GeneCards: PIR
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 15,384,799 bp[1] End 15,493,564 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F5 Start 164,269,371 bp[2] End 164,373,011 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • GO:0001948 protein binding • GO:0001104 transcription coregulator activity • dioxygenase activity • metal ion binding • quercetin 2,3-dioxygenase activity Cellular component • cytoplasm • cell nucleus • cytosol • nucleoplasm Biological process • myeloid cell differentiation • regulation of transcription, DNA-templated • oxidation-reduction process • monocyte differentiation • transcription from RNA polymerase II promoter • transcription, DNA-templated • digestion • regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8544	69656
Ensembl	ENSG00000087842	ENSMUSG00000031379
UniProt	O00625	Q9D711
RefSeq (mRNA)	NM_003662 NM_001018109	NM_001301402 NM_027153
RefSeq (protein)	NP_001018119 NP_003653	NP_001288331 NP_081429
Location (UCSC)	Chr X: 15.38 – 15.49 Mb	Chr X: 164.27 – 164.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.[6]

Interactions

PIR (gene) has been shown to interact with BCL3.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000087842 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031379 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
6. "Entrez Gene: PIR pirin (iron-binding nuclear protein)".
7. Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Adams M, Jia Z (2005). "Structural and biochemical analysis reveal pirins to possess quercetinase activity". J. Biol. Chem. 280 (31): 28675–82. doi:10.1074/jbc.M501034200. PMID 15951572.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Pang H, Bartlam M, Zeng Q, et al. (2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor". J. Biol. Chem. 279 (2): 1491–8. doi:10.1074/jbc.M310022200. PMID 14573596.
• Zeng Q, Li X, Bartlam M, et al. (2004). "Purification, crystallization and preliminary X-ray analysis of human pirin". Acta Crystallogr. D. 59 (Pt 8): 1496–8. doi:10.1107/S0907444903012289. PMID 12876364.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dechend R, Hirano F, Lehmann K, et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.