PIK3CG

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.

PIK3CG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E8Y, 1E8Z, 1HE8, 2A4Z, 2A5U, 2CHW, 2CHX, 2CHZ, 2V4L, 3APC, 3APD, 3APF, 3CSF, 3CST, 3DBS, 3ENE, 3IBE, 3L08, 3L13, 3L16, 3L17, 3L54, 3LJ3, 3MJW, 3ML8, 3ML9, 3NZS, 3NZU, 3OAW, 3P2B, 3PRE, 3PRZ, 3PS6, 3QAQ, 3QAR, 3QJZ, 3QK0, 3R7Q, 3R7R, 3S2A, 3SD5, 3T8M, 3TJP, 3TL5, 3ZVV, 3ZW3, 4ANU, 4ANV, 4ANW, 4ANX, 4AOF, 4DK5, 4EZJ, 4EZK, 4EZL, 4F1S, 4FA6, 4FAD, 4FHJ, 4FHK, 4FJY, 4FJZ, 4FLH, 4FUL, 4G11, 4GB9, 4HLE, 4HVB, 4J6I, 4KZ0, 4KZC, 4PS3, 4PS7, 4PS8, 4URK, 4WWN, 4WWO, 4WWP, 4XX5, 4XZ4, 5EDS, 5G2N
Identifiers
Aliases	PIK3CG, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
External IDs	OMIM: 601232 MGI: 1353576 HomoloGene: 68269 GeneCards: PIK3CG
EC number	2.7.11.1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.3 Start 106,865,278 bp[1] End 106,908,980 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A3 Start 32,173,473 bp[2] End 32,208,659 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • ephrin receptor binding • 1-phosphatidylinositol-4-phosphate 3-kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • phosphatidylinositol 3-kinase activity • ATP binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • kinase activity • 1-phosphatidylinositol-3-kinase activity • identical protein binding • phosphatidylinositol-3,4-bisphosphate 5-kinase activity Cellular component • cytoplasm • phosphatidylinositol 3-kinase complex • membrane • phosphatidylinositol 3-kinase complex, class IB • cytosol • mast cell granule • cell membrane Biological process • regulation of protein phosphorylation • G-protein coupled receptor signaling pathway • positive regulation of protein kinase B signaling • regulation of cell adhesion mediated by integrin • endocytosis • adaptive immune response • respiratory burst involved in defense response • positive regulation of MAP kinase activity • immune system process • positive regulation of cytosolic calcium ion concentration • T cell chemotaxis • cytokine production • GO:0048554 positive regulation of catalytic activity • secretory granule localization • dendritic cell chemotaxis • neutrophil chemotaxis • platelet activation • T cell proliferation • chemotaxis • protein phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphorylation • natural killer cell chemotaxis • angiogenesis • positive regulation of acute inflammatory response • phosphatidylinositol biosynthetic process • negative regulation of fibroblast apoptotic process • phosphatidylinositol 3-kinase signaling • negative regulation of triglyceride catabolic process • mast cell degranulation • inflammatory response • innate immune system • platelet aggregation • neutrophil extravasation • T cell activation • regulation of calcium ion transmembrane transport • cellular response to cAMP • hepatocyte apoptotic process • phosphatidylinositol-mediated signaling • negative regulation of cardiac muscle contraction • phosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • cell migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5294	30955
Ensembl	ENSG00000105851	ENSMUSG00000020573
UniProt	P48736	Q9JHG7
RefSeq (mRNA)	NM_001282426 NM_001282427 NM_002649	NM_001146200 NM_001146201 NM_020272
RefSeq (protein)	NP_001269355 NP_001269356 NP_002640	NP_001139672 NP_001139673 NP_064668
Location (UCSC)	Chr 7: 106.87 – 106.91 Mb	Chr 12: 32.17 – 32.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.[5]

Interactions

PIK3CG has been shown to interact with:

• BCR gene,[6][7][8]
• KRAS,[9]
• PIK3CD,[10] and
• PIK3R5.[11]

See also

• Class I PI 3-kinases
• p87PIKAP

References

1. GRCh38: Ensembl release 89: ENSG00000105851 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020573 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide".
6. Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941–8. doi:10.1038/sj.onc.1202024. PMID 9747873.
7. Salgia R, Sattler M, Pisick E, Li JL, Griffin JD (February 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Exp. Hematol. 24 (2): 310–3. PMID 8641358.
8. Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen SC, Zon G, Gewirtz AM, Perussia B, Calabretta B (July 1995). "Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells". Blood. 86 (2): 726–36. doi:10.1182/blood.V86.2.726.bloodjournal862726. PMID 7606002.
9. Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R (November 1999). "Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma". Eur. J. Biochem. 266 (1): 70–82. doi:10.1046/j.1432-1327.1999.00815.x. PMID 10542052.
10. Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
11. Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nürnberg B (January 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J. Cell Biol. 160 (1): 89–99. doi:10.1083/jcb.200210115. PMC 2172741. PMID 12507995.

Further reading

• Alloatti G, Montrucchio G, Lembo G, Hirsch E (2004). "Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease". Biochem. Soc. Trans. 32 (Pt 2): 383–6. doi:10.1042/BST0320383. PMID 15046613.
• Rommel C, Camps M, Ji H (2007). "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?". Nat. Rev. Immunol. 7 (3): 191–201. doi:10.1038/nri2036. PMID 17290298. S2CID 43376714.