PIK3CB

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.[5][6]

PIK3CB
Identifiers
Aliases	PIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
External IDs	OMIM: 602925 MGI: 1922019 HomoloGene: 21250 GeneCards: PIK3CB
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.3 Start 138,652,698 bp[1] End 138,834,928 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 99,036,654 bp[2] End 99,140,621 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • 1-phosphatidylinositol-4-phosphate 3-kinase activity • GO:0001948 protein binding • insulin receptor substrate binding • ATP binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol 3-kinase activity • phosphatidylinositol-3,4-bisphosphate 5-kinase activity Cellular component • cytosol • phosphatidylinositol 3-kinase complex • cell membrane • nucleolus • cell nucleus • midbody • cytoplasm • membrane • intracellular Biological process • G-protein coupled receptor signaling pathway • embryonic cleavage • endocytosis • positive regulation of autophagy • Fc-gamma receptor signaling pathway involved in phagocytosis • transmembrane receptor protein tyrosine kinase signaling pathway • angiogenesis involved in wound healing • cellular calcium ion homeostasis • regulation of cell-matrix adhesion • platelet activation • autophagy • Fc-epsilon receptor signaling pathway • chemotaxis • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphorylation • positive regulation of gene expression • vascular endothelial growth factor receptor signaling pathway • cell adhesion • activation of MAPK activity • response to wounding • endothelial cell proliferation • regulation of clathrin-dependent endocytosis • T cell receptor signaling pathway • platelet aggregation • cell migration • phosphatidylinositol-mediated signaling • leukocyte migration • signal transduction • homophilic cell adhesion via plasma membrane adhesion molecules • axon guidance • phosphorylation • adaptive immune response • inflammatory response • positive regulation of neutrophil apoptotic process • innate immune system • cell chemotaxis • positive regulation of protein kinase B signaling • phosphatidylinositol 3-kinase signaling • cytokine-mediated signaling pathway • protein phosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5291	74769
Ensembl	ENSG00000051382	ENSMUSG00000032462
UniProt	P42338	Q8BTI9
RefSeq (mRNA)	NM_001256045 NM_006219	NM_029094
RefSeq (protein)	NP_001242974 NP_006210	NP_083370
Location (UCSC)	Chr 3: 138.65 – 138.83 Mb	Chr 9: 99.04 – 99.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000051382 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032462 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hu P, Mondino A, Skolnik EY, Schlessinger J (Jan 1994). "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85". Mol Cell Biol. 13 (12): 7677–88. doi:10.1128/mcb.13.12.7677. PMC 364839. PMID 8246984.
6. "Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide".

Further reading

• Katada T, Kurosu H, Okada T, et al. (1999). "Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors". Chem. Phys. Lipids. 98 (1–2): 79–86. doi:10.1016/S0009-3084(99)00020-1. PMID 10358930.
• Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231. S2CID 11362623.
• Carpenter CL, Duckworth BC, Auger KR, et al. (1991). "Purification and characterization of phosphoinositide 3-kinase from rat liver". J. Biol. Chem. 265 (32): 19704–11. PMID 2174051.
• Bonnefoy-Bérard N, Liu YC, von Willebrand M, et al. (1995). "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10142–6. doi:10.1073/pnas.92.22.10142. PMC 40752. PMID 7479742.
• Hu P, Schlessinger J (1994). "Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta". Mol. Cell. Biol. 14 (4): 2577–83. doi:10.1128/mcb.14.4.2577. PMC 358625. PMID 8139559.
• Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481.
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793.
• Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID 9394803.
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID 9446795.
• Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. doi:10.1097/00002030-199811000-00008. PMID 9708406. S2CID 25758704.
• Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. doi:10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A. PMID 9808187.
• Graness A, Adomeit A, Heinze R, et al. (1998). "A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon". J. Biol. Chem. 273 (48): 32016–22. doi:10.1074/jbc.273.48.32016. PMID 9822674.
• Sotsios Y, Whittaker GC, Westwick J, Ward SG (1999). "The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes". J. Immunol. 163 (11): 5954–63. PMID 10570282.
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. doi:10.1182/blood.V97.2.352. PMID 11154208.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
• Yang H, Wang X, Raizada MK (2001). "Characterization of signal transduction pathway in neurotropic action of angiotensin II in brain neurons". Endocrinology. 142 (8): 3502–11. doi:10.1210/en.142.8.3502. PMID 11459796.
• Steták A, Csermely P, Ullrich A, Kéri G (2001). "Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta". Biochem. Biophys. Res. Commun. 288 (3): 564–72. doi:10.1006/bbrc.2001.5811. PMID 11676480.
• Ueki K, Yballe CM, Brachmann SM, et al. (2002). "Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 419–24. doi:10.1073/pnas.012581799. PMC 117575. PMID 11752399.