PHD finger protein 7

PHD finger protein 7 is a protein that in humans is encoded by the PHF7 gene. [5]

PHF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEQ
Identifiers
Aliases	PHF7, HSPC045, HSPC226, NYD-SP6, PHD finger protein 7
External IDs	MGI: 1919088 HomoloGene: 69217 GeneCards: PHF7
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.1 Start 52,410,660 bp[1] End 52,423,641 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 B Start 31,237,689 bp[2] End 31,251,317 bp[2]
Orthologs
Species	Human	Mouse
Entrez	51533	71838
Ensembl	ENSG00000010318	ENSMUSG00000021902
UniProt	Q9BWX1	Q9DAG9
RefSeq (mRNA)	NM_001278221 NM_016483 NM_173341 NM_001321126 NM_001321127	NM_027949 NM_001360624 NM_001360625
RefSeq (protein)	NP_001265150 NP_001308055 NP_001308056 NP_057567	NP_082225 NP_001347553 NP_001347554
Location (UCSC)	Chr 3: 52.41 – 52.42 Mb	Chr 14: 31.24 – 31.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells.

The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene.

References

1. GRCh38: Ensembl release 89: ENSG00000010318 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021902 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PHD finger protein 7". Retrieved 2017-09-05.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.