PHACTR3

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.[5][6]

PHACTR3
Identifiers
Aliases	PHACTR3, C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3
External IDs	OMIM: 608725 MGI: 1921439 HomoloGene: 14482 GeneCards: PHACTR3
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.32-q13.33 Start 59,577,509 bp[1] End 59,847,711 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 178,118,975 bp[2] End 178,338,492 bp[2]
Gene ontology Molecular function • protein phosphatase inhibitor activity • protein phosphatase 1 binding • actin binding • protein phosphatase regulator activity Cellular component • nuclear matrix • cell nucleus • nucleoplasm Biological process • negative regulation of phosphoprotein phosphatase activity • regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116154	74189
Ensembl	ENSG00000087495	ENSMUSG00000027525
UniProt	Q96KR7	Q8BYK5
RefSeq (mRNA)	NM_001199505 NM_001199506 NM_001281507 NM_080672 NM_183244 NM_183246	NM_001007154 NM_001177789 NM_001177790 NM_001177791 NM_028806
RefSeq (protein)	NP_001186434 NP_001186435 NP_001268436 NP_542403 NP_899067 NP_899069	NP_001007155 NP_001171260 NP_001171261 NP_001171262 NP_083082
Location (UCSC)	Chr 20: 59.58 – 59.85 Mb	Chr 2: 178.12 – 178.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.[6]

Interactions

PHACTR3 has been shown to interact with PPP1CA.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000087495 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027525 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A. 101 (18): 7187–92. doi:10.1073/pnas.0401673101. PMC 406487. PMID 15107502.
6. "Entrez Gene: PHACTR3 phosphatase and actin regulator 3".
7. Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.

Further reading

• Worch S, Fiedler E, Hansmann I, Schlote D (2006). "Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human". Cytogenet. Genome Res. 115 (1): 23–9. doi:10.1159/000094797. PMID 16974080. S2CID 38349132.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.