Oxathiapiprolin

Oxathiapiprolin
Names
	IUPAC name 1-[4-[4-[5-(2,6-Difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanone
Identifiers
CAS Number	1003318-67-9 ;
3D model (JSmol)	Interactive image;
ECHA InfoCard	100.227.885
PubChem CID	56945145;
UNII	56498AIV8R ;
CompTox Dashboard (EPA)	DTXSID30893604 ;
	InChI InChI=1S/C24H22F5N5O2S/c1-13-9-20(24(27,28)29)31-34(13)11-21(35)33-7-5-14(6-8-33)23-30-18(12-37-23)17-10-19(36-32-17)22-15(25)3-2-4-16(22)26/h2-4,9,12,14,19H,5-8,10-11H2,1H3 Key: IAQLCKZJGNTRDO-UHFFFAOYSA-N;
	SMILES CC1=CC(=NN1CC(=O)N2CCC(CC2)C3=NC(=CS3)C4=NOC(C4)C5=C(C=CC=C5F)F)C(F)(F)F;
Properties
Chemical formula	C24H22F5N5O2S
Molar mass	539.53 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Oxathiapiprolin (trade names Zorvec and Segovis) is a fungicide. In the United States, the Environmental Protection Agency has approved it for use against several fungal diseases including downy mildew and late blight on crops including vegetables, ornamentals, and turf.[1]

Its mechanism of action involves binding to the oxysterol-binding protein in Oomycetes.[2][3]

References

"Oxathiapiprolin" (PDF). New Active Ingredient Review. Minnesota Department of Agriculture. October 2015. Archived from the original (PDF) on 2017-11-07. Retrieved 2017-11-03.
Cohen, Yigal (2015). "The Novel Oomycide Oxathiapiprolin Inhibits All Stages in the Asexual Life Cycle of Pseudoperonospora cubensis - Causal Agent of Cucurbit Downy Mildew". PLoS ONE. 10 (10): e0140015. Bibcode:2015PLoSO..1040015C. doi:10.1371/journal.pone.0140015. PMC 4599937. PMID 26452052.
Pasteris, Robert J; Hanagan, Mary Ann; Bisaha, John J; Finkelstein, Bruce L; Hoffman, Lisa E; Gregory, Vann; Shepherd, Christopher P; Andreassi, John L; Sweigard, James A; Klyashchitsky, Boris A; Henry, Yewande T; Berger, Richard A (2015). "The Discovery of Oxathiapiprolin: A New, Highly-Active Oomycete Fungicide with a Novel Site of Action". Discovery and Synthesis of Crop Protection Products. ACS Symposium Series. 1204. p. 149. doi:10.1021/bk-2015-1204.ch011. ISBN 978-0-8412-3102-3.

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[1] "Oxathiapiprolin" (PDF). New Active Ingredient Review. Minnesota Department of Agriculture. October 2015. Archived from the original (PDF) on 2017-11-07. Retrieved 2017-11-03.

[2] Cohen, Yigal (2015). "The Novel Oomycide Oxathiapiprolin Inhibits All Stages in the Asexual Life Cycle of Pseudoperonospora cubensis - Causal Agent of Cucurbit Downy Mildew". PLoS ONE. 10 (10): e0140015. Bibcode:2015PLoSO..1040015C. doi:10.1371/journal.pone.0140015. PMC 4599937. PMID 26452052.

[3] Pasteris, Robert J; Hanagan, Mary Ann; Bisaha, John J; Finkelstein, Bruce L; Hoffman, Lisa E; Gregory, Vann; Shepherd, Christopher P; Andreassi, John L; Sweigard, James A; Klyashchitsky, Boris A; Henry, Yewande T; Berger, Richard A (2015). "The Discovery of Oxathiapiprolin: A New, Highly-Active Oomycete Fungicide with a Novel Site of Action". Discovery and Synthesis of Crop Protection Products. ACS Symposium Series. 1204. p. 149. doi:10.1021/bk-2015-1204.ch011. ISBN 978-0-8412-3102-3.