Occupational cancer

Occupational cancer is cancer caused by occupational hazards. Several cancers have been directly tied to occupational hazards, including chimney sweeps' carcinoma, mesothelioma, and others.

Common occupational hazards implicated in cancer

Occupational exposure to chemicals, dusts, radiation, and certain industrial processes have been tied to occupational cancer. Exposure to cancer-causing chemicals (carcinogens) may cause mutations that allow cells to grow out of control, causing cancer. Carcinogens in the workplace may include chemicals like anilines, chromates, dinitrotoluenes, arsenic and inorganic arsenic compounds, beryllium and beryllium compounds, cadmium compounds, and nickel compounds.[1] Dusts that can cause cancer leather or wood dusts, asbestos,[2] crystalline forms of silica, coal tar pitch volatiles, coke oven emissions, diesel exhaust and environmental tobacco smoke.[1] sunlight; radon gas; and industrial, medical, or other exposure to ionizing radiation can all cause cancer in the workplace. Industrial processes associated with cancer include aluminum production; iron and steel founding; and underground mining with exposure to uranium or radon. Shift work, which can disturb the circadian rhythm, has also been identified as a risk factor for some forms of cancer, in particular for breast cancer. [3][4][5]

Other factors that play a role in cancer include:[6]

• Personal characteristics such as age, sex, and race
• Family history of cancer
• Diet and personal habits such as cigarette smoking and alcohol consumption
• The presence of certain medical conditions or past medical treatments, including chemotherapy, radiation treatment, or some immune-system suppressing drugs.
• Exposure to cancer-causing agents in the environment (for example, sunlight, radon gas, air pollution, and infectious agents)

Occupational cancers

Common cancers and their exposures and occupations include:[2]

Cancer	Source	Examples of Occupations
Bladder	Benzidine, beta-naphthylamine, 4-aminobiphenyl, arsenic	Rubber, leather, paving, roofing, printing and textile industries; paint/ dyeing products; chimney sweeping; machinists; hairdressers and barbers; truck drivers
Kidney	Cadmium, trichloroethylene, herbicides, wood dust	Painting; metalworking; petroleum, plastics, and textile industries
Larynx	Asbestos, wood dust, paint fumes	Metal working; petroleum, rubber, plastics, and textile industries
Leukemia	Formaldehyde, benzene, ethylene oxide, pesticides	Rubber manufacturing; oil refining; shoemaking, funeral embalming
Liver	Arsenic, vinyl chloride, aflatoxins	Plastic manufacturing
Lung	Radon, secondhand smoke, asbestos, arsenic, cadmium, chromium compounds, diesel exhaust, sulfur mustard	Rubber manufacturing, paving, roofing, painting, chimney sweeping, iron and steel foundry work, welding
Lymphoma	Benzene, 1, 3-butadiene, ethylene oxide, herbicides, insecticides	Rubber manufacturing, painting, hairdresser or barber
Mesothelioma	Asbestos	Mining, railroad, automotive, plumbing, painting and construction industries; factory workers
Nasal cavity and sinus	Mustard gas, nickel dust, chromium dust, leather dust, wood dust, radium	Textile and baking industry, flour milling, nickel refining, furniture and cabinet builders, shoemaking
Skin	Arsenic, coal tars, paraffin, certain oils, sunlight	Chimney sweeping; outside jobs that involve a lot of sun exposure

Epidemiology

An estimated 48,000 cancers are diagnosed yearly in the US that come from occupational causes; this represents approximately 4-10% of total cancer in the United States.[7] It is estimated that 19% of cancers globally are attributed to environmental exposures (including work-related exposures).[8]

Prevention

Many occupational cancers are preventable. Personal protective gear, workplace controls, and worker education can prevent exposure to carcinogens in the workplace. Tobacco smoking has also been shown to increase the risk of work-related cancers; decreasing or abstaining from smoking can decrease cancer risk.[2]

Agencies like the US Food and Drug Administration, Environmental Protection Agency, the International Agency for Research on Cancer (IARC) and Occupational Safety and Health Administration have developed safety standards and limits for chemical and radiation exposure.[2]

References

1. "Carcinogen List". National Institute for Occupational Safety and Health. 2 May 2012. Retrieved 5 January 2014.
2. "Occupation and Cancer" (PDF). American Cancer Society. January 2016. Retrieved 12 February 2016.
3. Fritschi L (July 2009). "Shift work and cancer". BMJ. 339: b2653. doi:10.1136/bmj.b2653. ISSN 0959-8138. PMID 19605423. S2CID 36132408.
4. Stevens RG, Hansen J, Costa G, Haus E, Kauppinen T, Aronson KJ, et al. (February 2011). "Considerations of circadian impact for defining 'shift work' in cancer studies: IARC Working Group Report". Occup Environ Med. 68 (2): 154–62. doi:10.1136/oem.2009.053512. ISSN 1351-0711. PMID 20962033. S2CID 16553063.
5. Megdal SP, Kroenke CH, Laden F, Pukkala E, Schernhammer ES (September 2005). "Night work and breast cancer risk: a systematic review and meta-analysis". Eur. J. Cancer. 41 (13): 2023–32. doi:10.1016/j.ejca.2005.05.010. PMID 16084719.
6. "CDC - Cancer Policy - NIOSH Workplace Safety and Health Topic". www.cdc.gov. Retrieved 2016-02-12.
7. "Occupational Cancer". National Institute for Occupational Safety and Health. 2 May 2012. Retrieved 5 January 2014.
8. "Environmental and occupational cancers". World Health Organization. Retrieved 2016-02-12.