ONECUT1

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. [5]

ONECUT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S7E
Identifiers
Aliases	ONECUT1, HNF-6, HNF6, HNF6A, one cut homeobox 1
External IDs	OMIM: 604164 MGI: 1196423 HomoloGene: 3309 GeneCards: ONECUT1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.3 Start 52,755,053 bp[1] End 52,791,078 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 41.93 cM Start 74,861,921 bp[2] End 74,891,781 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • Notch signaling pathway • epithelial cell development • cell differentiation • cell fate commitment • endoderm development • regulation of transcription, DNA-templated • positive regulation of cell migration • regulation of transcription from RNA polymerase II promoter • anatomical structure morphogenesis • negative regulation of transforming growth factor beta receptor signaling pathway • spleen development • transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of cell-matrix adhesion • glucose metabolic process • pancreas development • liver development • B cell differentiation • positive regulation of transcription from RNA polymerase II promoter • system development • endocrine pancreas development • cilium morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3175	15379
Ensembl	ENSG00000169856	ENSMUSG00000043013
UniProt	Q9UBC0	O08755
RefSeq (mRNA)	NM_004498	NM_008262
RefSeq (protein)	NP_004489	NP_032288
Location (UCSC)	Chr 15: 52.76 – 52.79 Mb	Chr 9: 74.86 – 74.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

References

1. GRCh38: Ensembl release 89: ENSG00000169856 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043013 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: One cut homeobox 1". Retrieved 2016-04-13.

Further reading

• Rausa FM, Tan Y, Costa RH (2003). "Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding". Mol. Cell. Biol. 23 (2): 437–49. doi:10.1128/mcb.23.2.437-449.2003. PMC 151533. PMID 12509444.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.