ODF2

Outer dense fiber protein 2, also known as cenexin, is a protein that in humans is encoded by the ODF2 gene.[5][6][7]

ODF2
Identifiers
AliasesODF2, CT134, ODF2/1, ODF2/2, ODF84, outer dense fiber of sperm tails 2
External IDsOMIM: 602015 MGI: 1098824 HomoloGene: 1907 GeneCards: ODF2
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q34.11Start128,455,186 bp[1]
End128,501,292 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4957

18286

Ensembl

ENSG00000136811

ENSMUSG00000026790

UniProt

Q5BJF6

A3KGV1

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 9: 128.46 – 128.5 MbChr 2: 29.89 – 29.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of this gene; however, not all isoforms and variants have been fully described.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000136811 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026790 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shao X, Tarnasky HA, Schalles U, Oko R, van der Hoorn FA (Apr 1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27". J Biol Chem. 272 (10): 6105–13. doi:10.1074/jbc.272.10.6105. PMID 9045620.
  6. Shao X, Murthy S, Demetrick DJ, van der Hoorn FA (Mar 1999). "Human outer dense fiber gene, ODF2, localizes to chromosome 9q34". Cytogenet Cell Genet. 83 (3–4): 221–3. doi:10.1159/000015183. hdl:1807.1/828. PMID 10072582. S2CID 1214379.
  7. "Entrez Gene: ODF2 outer dense fiber of sperm tails 2".

Further reading


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