O. H. Frazier

O. H. "Bud" Frazier is a heart surgeon and director of cardiovascular surgery research at the Texas Heart Institute (THI), best known for his work in mechanical circulatory support (MCS) of failing hearts using left ventricular assist devices (LVAD) and total artificial hearts (TAH).

O. H. Frazier
Born
Oscar Howard Frazier Jr.

1940
Stephenville, Texas
NationalityAmerican
Education
OccupationCardiovascular surgeon
Known for
  • First U.S. implantation of the HeartMate II pump into a human
  • First implantation of the Jarvik 2000 into a human
  • First successful implantation of a continuous-flow TAH into a human
Medical career
ProfessionCardiovascular surgeon
InstitutionsBaylor St. Luke's Medical Center
The University of Texas Health Science Center at Houston
Research
AwardsISHLT Lifetime Achievement Award 2018

His achievements in heart surgery include the implantation of the first long-term LVAD, the pulsatile HeartMate I in 1986, and the replacement of a diseased heart with a continuous flow device using two HeartMate II pumps, in 2011. His most significant achievements have been in the development of the non-pulsatile implantable LVADs, the Jarvik, HeartMate II and HeartWare.

In 1963, Frazier entered medicine at Baylor College of Medicine (BCM) on completion of a degree in history from the University of Texas-Austin. Under the mentorship of at first Michael E. DeBakey at BCM, and then Denton Cooley at the THI, he performed research on the testing of LVADs as a form of MCS. He continued to lead and become significantly influential in heart surgery and the development and clinical implementation of LVADs and his surgical career at the THI has spanned over fifty years.

Other positions have included chief of the transplant service at Baylor St. Luke's Medical Center (part of the Catholic Health Initiatives system) in Houston.

Early life and education

Oscar Howard Frazier Jr. was born and grew up in Stephenville, Texas, in a Methodist household. Both his parents were teachers[1][2] and his grandfather nicknamed him "Bud" after a distant cousin who was killed in a West Texas saloon shootout at the turn of the nineteenth century.[1]

A "former high school football star",[3] he was initially destined for a career in football,[2] having been asked by Darrell Royal to play for the University of Texas at Austin as a kicker.[1] However, after attending only a few two-a-day football practices, a leg injury ended his football career.[2] Despite this, he later became a black belt in Karate.[2] 

Frazier, at first gained admission to study history and literature at law school,[1] but switched to medicine, after being influenced by the writings of Anton Chekhov and William Carlos Williams.[1][2][4] Interviewed for medicine on the 4 July, he won a place at Baylor College of Medicine, atypically on the ability to answer a question on history.[1] He subsequently completed his BA degree in history from the University of Texas-Austin in 1963 before commencing medical education.[5]

Medical education
Baylor College of Medicine (BCM)

As a medical student at BCM in 1964, he assisted in experimental total artificial hearts (TAH) research, which placed him under the mentorship of Michael E. DeBakey, Domingo Liotta and Denton A. Cooley,[1][6] who five years later, controversially became the first to implant one.[7]

In 1966, at the age of 25, while still a medical student of DeBakey, who he described as a “tough taskmaster”,[8] an experience with a teenager who had just had an aortic valve repair, left a lasting impression on him. Frazier was required to manually massage the teenager's heart following a cardiac arrest. He has since repeatedly recounted "that as long as I was massaging that kid's heart, he would wake up... I thought then, and I've often returned to this: If my hand can keep this kid alive, why couldn't we make a device to do the same?"[9] It was this incident and the experience with DeBakey's research that instilled his interest in cardiac surgery and MCS's.[6]

Of the twenty four students that Frazier started his residency with, only five were left. DeBakey, intolerable of error, fired most.[1]

Upon graduating with an MD in 1967, he also received the DeBakey Award for Outstanding Surgical Student[10] before then completing his residency at Baylor Affiliated Hospitals in 1968.[5]

Vietnam

Frazier served in the United States Army from 1968 to 1970 and distinguished himself as a flight surgeon in the U.S. Army 48th Assault Helicopter Company in Vietnam.[5] Once, he was shot down and on return to the States, has described how demoralised he felt about what men were capable of during war.[1]

For his achievements, he received three medals, the Combat Flight Medal, Vietnamese Navy Medal, and the Vietnamese Distinguished Service Medal.[2]

Surgical career

After Vietnam, Frazier returned as a surgical resident to BCM.[5]

He remained at BCM until 1974 when he gravitated towards LVAD-research at the near-by THI and subsequently joined Baylor’s new rival Cooley, at the THI for further surgical training, which he completed in 1976.[5][7][10]

Left ventricular assist devices (LVAD) and total artificial hearts (TAH)

Throughout the 1970s and 1980s, he continued experimental work toward the development of the implantable long-term pulsatile HeartMate I LVAD.[6][11] In 1976, he worked with John C. Norman and the first intra-abdominal LVAD.[11] In 1985, during his tenure on the advisory board of the National Heart, Lung, and Blood Institute (NHLBI), Frazier recommended that research be initiated on a TAH that would be fully implantable and that would allow people to be discharged and to live a normal lifestyle.[12] In 1986, Frazier successfully used the HeartMate I LVAD in a person with severe irreversible heart failure who was waiting for a heart transplant. Driven by compressed air, the HeartMate LVAD had a textured blood-contacting inner surface, in contrast to a smooth surface. This encouraged a living lining of endothelial cells resembling the inner surfaces of arteries and veins and hence required less blood thinning drugs.[6][10][11]

Over the course of four decades, his work in the field of other LVAD prototypes, continued with experimental studies that resulted in the first intravascular, implantable, continuous-flow pump (Hemopump), which he first implanted into a human in April 1988.[12][13]

When funding for TAH research was restored in January 1991, Frazier became involved in further animal experiments.[12] In 1994, he instigated research on the HeartWare LVAD and described the first long-term clinical use of a LVAD. This person was the first to make hospital discharge with a LVAD.[10] His most significant contribution was the development of the nonpulsatile implantable LVADs, the Jarvik, HeartMate II and HeartWare.[6] After more than ten years of research, in 2000, he performed the first implant of the Jarvik 2000 LVAD into a human, also a continuous flow pump.[1]

By the end of 2013, Frazier and his THI team had implanted their 1,000th LVAD, more than fifty years after Cooley founded the THI and just short of fifty years after DeBakey at BCM was awarded the original NHI grant for the development of an artificial heart.[10][14] His innovations in the surgical treatment of severe heart failure, heart transplantation and MCS to be used either to substitute for or to assist the pumping action of the human heart led to the THI gaining a reputation as a global leader of transplantation and MCS programmes. Frazier performed more than 1,300 heart transplants and implanted 1,000 LVADs, exceeding the performance of any other contemporary surgeon in the world during his career.[6][11]

Successful implantation of a continuous flow device
‘Heartmate’ left ventricular-assist device, United States Wellcome L0066304

In March 2011, Craig Lewis was suffering from amyloidosis and not eligible for heart transplant due to the severity and extent of the disease, affecting also his kidney and liver. Unsuitable for a heart transplant, temporary mechanical TAH or LVAD, his small diseased heart was replaced with a continuous flow device, a pair of HeartMate II pumps, an apparatus of two pumps embraced together, following six years of research on more than fifty calves at the Texas Institute. He awoke from a coma and spent the last five weeks of his life interacting with his family. During the following year, Frazier and his colleague William Cohn engaged with the public and professionals on their experiences. Their TEDMED talk introduced them to Daniel Timms, who was driven to find a technological resolution and whose father had died of heart failure. Timms had an idea and sought out Frazier and Cohn in the States. The surgeons became interested, particularly with the idea that Timms's device had the potential to be a small size. Trialed in numerous calves between 2013 and 2016, some were able to run a treadmill after implantation.[15][16]

Appointments

Frazier has been Professor of surgery at the University of Texas Health Science Center in Houston,[17] Clinical professor of surgery at the University of Texas M.D. Anderson Cancer Center, and Tenured professor at BCM[18]

He has served on the editorial boards of several medical journals, including Circulation, the Journal of the American Heart Association, and The Journal of Heart and Lung Transplantation.[5]

He was a chairman of the federal affairs committee for the American Society for Artificial Internal Organs and served on other prominent national committees, including the education committee of the American Society of Transplant Surgeons and the advisory board of the NHLBI.[12]

Frazier served as president of The Denton A. Cooley Surgical Society and the American Society for Artificial Internal Organs.

Awards and honors

Medical honors include the Living Legend Award from the World Society of Cardiothoracic Surgeons, BCM Distinguished Alumnus Award, University of Texas Distinguished Alumnus Award, the Gift to Mankind Award from the American Organ Transplant Association, the Distinguished Surgeon Award from the Houston Surgical Society, Honored Physician Award from the American Heart Association Guild, the Ray C. Fish Award for Scientific Achievement from the Texas Heart Institute[18] and the Denton A. Cooley Cardiovascular Surgical Society International Recognition Award. In 2014, Dr. Frazier was presented with the Lifetime Achievement and Distinguished Faculty Award from the Michael E. DeBakey department of surgery at BCM. Frazier's award presentation preceded keynote speaker, former Vice President Dick Cheney, whose life was extended by the technology Frazier helped to develop.[19]

Since 2014, the International Society of Heart and Lung Transplantation (ISHLT) has awarded the "O.H. Frazier Award" in MCS Translational Research sponsored by Medtronic.[20]

In 2018, the ISHLT awarded Frazier with their ISHLT Lifetime Achievement Award in acknowledgement of his work on severe heart failure, heart transplantation and mechanical circulatory support.[6]

Published in 2018, a book entitled Ticker, recounts the story of Frazier’s task to construct a sustainable totally implantable artificial heart.[21] The author describes Frazier sharing traits with pioneers in other fields[22] and how for over half a century been driven by the desire to save lives.[21] In response, reviewers have either been intrigued to what drives Frazier[21] or have debated the ethics surrounding TAHs and LVADs.[22]

Personal and family

Frazier has previously led Sunday school and collects rare books.[2] He is married to Rachel, and they have two children, Todd, who graduated from the Juilliard School of Music and became a composer, and Allison, a writer.[1]

Selected publications
  • Frazier, O.H. (1996). "Evolution of battery-powered, vented left ventricular assist devices". The Annals of Thoracic Surgery. 61 (1): 393–395. doi:10.1016/0003-4975(95)00945-0. PMID 8561612.
  • Norman, John C. (1981). "Intracorporeal (Abdominal) Left Ventricular Assist Devices or Partial Artificial Hearts". Archives of Surgery. 116 (11): 1441–5. doi:10.1001/archsurg.1981.01380230059009. PMID 7305657..
  • Frazier, OH; Rose, EA; McCarthy, P; Burton, NA; Tector, A; Levin, H; Kayne, HL; Poirier, VL; Dasse, KA (1995). "Improved mortality and rehabilitation of transplant candidates treated with a long-term implantable left ventricular assist system". Ann Surg. 222 (3): 327–36, discussion 336-8. doi:10.1097/00000658-199509000-00010. PMC 1234813. PMID 7677462.
  • Frazier, O.H.; Delgado, Reynolds M. (2003). "Mechanical Circulatory Support for Advanced Heart Failure". Circulation. 108 (25): 3064–3068. doi:10.1161/01.CIR.0000090962.04121.9E. PMID 14691020..
  • Gemmato, CJ; Forrester, MD; Myers, TJ; Frazier, OH; Cooley, DA (2005). "Thirty-five years of mechanical circulatory support at the Texas Heart Institute: an updated overview". Tex Heart Inst J. 32: 168–77. PMC 1163464. PMID 16107108.
  • Frazier, O.H. (2014). "Mechanical circulatory assist device development at the Texas Heart Institute: A personal perspective". The Journal of Thoracic and Cardiovascular Surgery. 147 (6): 1738–1744. doi:10.1016/j.jtcvs.2014.04.019. PMID 24837720.

References
  1. Berger, Eric (29 April 2007). "Houstonsurgeon a leader in heart transplant field". Houston Chronicle. Retrieved 8 November 2018.
  2. Communications, Emmis (October 1993). TheAlcalde. Emmis Communications. p. 43.
  3. Patsilelis, Chris. "Mimi Swartz's 'Ticker': The astonishing half-century quest for an artificial human heart". The Inquirer. Retrieved 7 November 2018.
  4. White, Andrea (14 March 2015). "Bigidea: Replacing the human heart". HoustonChronicle.com. Retrieved 8 November 2018.
  5. "O. H. Frazier, M.D., Distinguished Cardiopulmonary Transplantat Surgeon, Scientist, and Academician". 7 December 2013. Archived from the original on 2013-12-07. Retrieved 7 November 2018.
  6. "Dr. Frazier Awarded 2018 ISHLT Lifetime Achievement Award". Baylor College of Medicine. Retrieved 7 November 2018.
  7. Altman, Lawrence K. "Dr. Michael E. DeBakey and Dr. Denton A. Cooley - Heart Surgeons- The Feud". The New York Times. Retrieved 9 November 2018.
  8. "Transcript: DeBakey Video Profile". www.nlm.nih.gov. Retrieved 7 November 2018.
  9. De Jesus, Marie D. (18 April 2017). "Five decades later, famed surgeon Bud Frazier continues quest for an artificial heart". HoustonChronicle.com. Retrieved 7 November 2018.
  10. Rosengart, Todd K. (2014). "The 1,000th VAD, the great rivalry, and the grand experiment of the Texas Medical Center". The Journal of Thoracic and Cardiovascular Surgery. 147 (6): 1745–1747. doi:10.1016/j.jtcvs.2014.02.040. ISSN 0022-5223. PMID 24837721.
  11. McKellar, Shelley (2018). Artificial Hearts: The Allure and Ambivalence of a Controversial Medical Technology. Johns Hopkins University Press. pp. 194–195. ISBN 978-1-4214-2355-5.
  12. Fox, Renee C. (2017). Spare Parts: Organ Replacement in American Society. Routledge. ISBN 9781351488525.
  13. Morgan, Jeffrey A.; Civitello, Andrew B.; Frazier, O. H. (2017-12-06). Mechanical Circulatory Support for Advanced Heart Failure: A Texas Heart Institute/Baylor College of Medicine Approach. Springer. ISBN 9783319653648.
  14. McKellar, Shelley (2018), p.318
  15. Walker, Andy; Walker, Kay Svela; Carruthers, Sean (2016). Super You: How Technology is Revolutionizing What It Means to Be Human. Que Publishing. p. 198. ISBN 9780133790702.
  16. Baum, Dan (29 February 2012). "No Pulse: How Doctors Reinvented The Human Heart". Popular Science. Retrieved 7 November 2018.
  17. "O.H. Frazier, MD | Texas Heart Institute". www.texasheart.org. Retrieved 6 November 2018.
  18. "O Howard Frazier, M.D." Baylor College of Medicine. Retrieved 6 November 2018.
  19. "Surgery News" (PDF). Baylor College of Medicine-. 2014. p. 4.
  20. Transplantation, International Society for Heart & Lung (24 March 2017). ISHLT 2017 Final Program. CTI Meeting Technology.
  21. Sofia, Sokolove (1 November 2018). "A New Book Tells the Story of Longhorn O.H. "Bud" Frazier and His Quest to Build an Artificial Heart". The Alcalde. Retrieved 8 November 2018.
  22. Zhang, Sarah (17 September 2018). "The Quest to Create and Perfect an Artificial Heart". The New York Times. Retrieved 7 November 2018.
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