Nitric oxide reductase (cytochrome c)

Nitric oxide reductase (cytochrome c) (EC 1.7.2.5) is an enzyme with systematic name nitrous oxide:ferricytochrome-c oxidoreductase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

nitrous oxide + 2 ferricytochrome c + H2O 2 nitric oxide + 2 ferrocytochrome c + 2 H+
Nitric oxide reductase (cytochrome c)
Identifiers
EC number1.7.2.5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme from Pseudomonas aeruginosa contains a dinuclear centre.

References
  1. Hendriks J, Warne A, Gohlke U, Haltia T, Ludovici C, Lübben M, Saraste M (September 1998). "The active site of the bacterial nitric oxide reductase is a dinuclear iron center". Biochemistry. 37 (38): 13102–9. doi:10.1021/bi980943x. PMID 9748316.
  2. Hendriks J, Gohlke U, Saraste M (February 1998). "From NO to OO: nitric oxide and dioxygen in bacterial respiration". Journal of Bioenergetics and Biomembranes. 30 (1): 15–24. doi:10.1023/A:1020547225398. PMID 9623801.
  3. Heiss B, Frunzke K, Zumft WG (June 1989). "Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri". Journal of Bacteriology. 171 (6): 3288–97. PMC 210048. PMID 2542222.
  4. Cheesman MR, Zumft WG, Thomson AJ (March 1998). "The MCD and EPR of the heme centers of nitric oxide reductase from Pseudomonas stutzeri: evidence that the enzyme is structurally related to the heme-copper oxidases". Biochemistry. 37 (11): 3994–4000. doi:10.1021/bi972437y. PMID 9521721.
  5. Kumita H, Matsuura K, Hino T, Takahashi S, Hori H, Fukumori Y, Morishima I, Shiro Y (December 2004). "NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single turnover cycle". The Journal of Biological Chemistry. 279 (53): 55247–54. doi:10.1074/jbc.M409996200. PMID 15504726.
  6. Hino T, Matsumoto Y, Nagano S, Sugimoto H, Fukumori Y, Murata T, Iwata S, Shiro Y (December 2010). "Structural basis of biological N2O generation by bacterial nitric oxide reductase". Science. 330 (6011): 1666–70. doi:10.1126/science.1195591. PMID 21109633.
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