Natriuretic peptide precursor C

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.[5][6][7] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

NPPC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JDP
Identifiers
Aliases	NPPC, CNP, CNP2, Natriuretic peptide precursor C, natriuretic peptide C
External IDs	OMIM: 600296 MGI: 97369 HomoloGene: 7867 GeneCards: NPPC
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 231,921,809 bp[1] End 231,926,396 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C5|1 43.98 cM Start 86,666,291 bp[2] End 86,670,571 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • hormone activity • peptide hormone receptor binding • receptor binding • hormone receptor binding Cellular component • secretory granule • extracellular region • extracellular • macromolecular complex Biological process • animal organ development • negative regulation of meiotic cell cycle • regulation of cardiac conduction • growth plate cartilage chondrocyte proliferation • response to hypoxia • ossification • regulation of multicellular organism growth • negative regulation of oocyte maturation • growth plate cartilage chondrocyte differentiation • post-embryonic development • receptor guanylyl cyclase signaling pathway • regulation of smooth muscle cell proliferation • cGMP biosynthetic process • positive regulation of osteoblast differentiation • negative regulation of DNA metabolic process • response to ethanol • response to drug • negative regulation of cell proliferation • protein folding • positive regulation of blood vessel diameter • regulation of receptor activity • reproductive process • cGMP-mediated signaling • positive regulation of cGMP-mediated signaling • negative regulation of collagen biosynthetic process • negative regulation of DNA biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4880	18159
Ensembl	ENSG00000163273	ENSMUSG00000026241
UniProt	P23582	Q61839
RefSeq (mRNA)	NM_024409	NM_010933
RefSeq (protein)	NP_077720	NP_035063
Location (UCSC)	Chr 2: 231.92 – 231.93 Mb	Chr 1: 86.67 – 86.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[5] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).[8] It is synthesized and secreted from the endothelium in response to many stimuli, for example shear stress (like NO) and certain proinflammatory cytokines.[9]

Structure of C-type natriuretic peptide (human)

References

1. GRCh38: Ensembl release 89: ENSG00000163273 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026241 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NPPC natriuretic peptide precursor C".
6. Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189. S2CID 41367489.
7. Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
8. Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763. S2CID 9083211.
9. Lumsden NG, Khambata RS, Hobbs AJ (2010). "C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target". Current Pharmaceutical Design. 16 (37): 4080–8. doi:10.2174/138161210794519237. PMC 3605774. PMID 21247399.

Further reading

• Schulz S (June 2005). "C-type natriuretic peptide and guanylyl cyclase B receptor". Peptides. 26 (6): 1024–34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070. S2CID 24299700.
• Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K (January 1992). "Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide". Endocrinology. 130 (1): 229–39. doi:10.1210/en.130.1.229. PMID 1309330.
• Ogawa Y, Nakao K, Nakagawa O, Komatsu Y, Hosoda K, Suga S, Arai H, Nagata K, Yoshida N, Imura H (June 1992). "Human C-type natriuretic peptide. Characterization of the gene and peptide". Hypertension. 19 (6 Pt 2): 809–13. doi:10.1161/01.hyp.19.6.809. PMID 1339402.
• Ishizaka Y, Kangawa K, Minamino N, Ishii K, Takano S, Eto T, Matsuo H (December 1992). "Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1". Biochemical and Biophysical Research Communications. 189 (2): 697–704. doi:10.1016/0006-291X(92)92257-X. PMID 1472040.
• Komatsu Y, Nakao K, Suga S, Ogawa Y, Mukoyama M, Arai H, Shirakami G, Hosoda K, Nakagawa O, Hama N (August 1991). "C-type natriuretic peptide (CNP) in rats and humans". Endocrinology. 129 (2): 1104–6. doi:10.1210/endo-129-2-1104. PMID 1855454.
• Tawaragi Y, Fuchimura K, Tanaka S, Minamino N, Kangawa K, Matsuo H (March 1991). "Gene and precursor structures of human C-type natriuretic peptide". Biochemical and Biophysical Research Communications. 175 (2): 645–51. doi:10.1016/0006-291X(91)91614-I. PMID 2018508.
• Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
• Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189. S2CID 41367489.
• Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC (September 1993). "Natriuretic peptide system in human heart failure". Circulation. 88 (3): 1004–9. doi:10.1161/01.cir.88.3.1004. PMID 8353861.
• Igaki T, Itoh H, Suga S, Komatsu Y, Ogawa Y, Doi K, Yoshimasa T, Nakao K (July 1996). "Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide". Diabetes. 45 Suppl 3: S62–4. doi:10.2337/diab.45.3.s62. PMID 8674895. S2CID 24148723.
• Igaki T, Itoh H, Suga S, Hama N, Ogawa Y, Komatsu Y, Mukoyama M, Sugawara A, Yoshimasa T, Tanaka I, Nakao K (June 1996). "C-type natriuretic peptide in chronic renal failure and its action in humans". Kidney International Supplements. 55: S144–7. PMID 8743538.
• Vollmar AM, Paumgartner G, Gerbes AL (January 1997). "Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver". Gut. 40 (1): 145–50. doi:10.1136/gut.40.1.145. PMC 1027025. PMID 9155593.
• Watanabe Y, Nakajima K, Shimamori Y, Fujimoto Y (June 1997). "Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11". Biochemical and Molecular Medicine. 61 (1): 47–51. doi:10.1006/bmme.1997.2584. PMID 9232196.
• Martick MM, Garcia KC (August 2001). "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone". Science. 293 (5535): 1657–62. doi:10.1126/science.1062246. PMID 11533490. S2CID 6030635.
• Cataliotti A, Giordano M, De Pascale E, Giordano G, Castellino P, Jougasaki M, Costello LC, Boerrigter G, Tsuruda T, Belluardo P, Lee SC, Huntley B, Sandberg S, Malatino LS, Burnett JC (September 2002). "CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome". American Journal of Physiology. Renal Physiology. 283 (3): F464–72. doi:10.1152/ajprenal.00372.2001. PMID 12167597.
• Evans JJ, Youssef AH, Yandle TG, Lewis LK, Nicholls MG (October 2002). "Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells". The Journal of Endocrinology. 175 (1): 225–32. CiteSeerX 10.1.1.550.4618. doi:10.1677/joe.0.1750225. PMID 12379507.
• Ono K, Mannami T, Baba S, Tomoike H, Suga S, Iwai N (September 2002). "A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension". Hypertension Research. 25 (5): 727–30. doi:10.1291/hypres.25.727. PMID 12452325.
• Hirsch JR, Skutta N, Schlatter E (August 2003). "Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B". American Journal of Physiology. Renal Physiology. 285 (2): F370–4. doi:10.1152/ajprenal.00049.2003. PMID 12709393.
• Wu C, Wu F, Pan J, Morser J, Wu Q (July 2003). "Furin-mediated processing of Pro-C-type natriuretic peptide". The Journal of Biological Chemistry. 278 (28): 25847–52. doi:10.1074/jbc.M301223200. PMID 12736257.

External links

• C-Type+Natriuretic+Peptide at the US National Library of Medicine Medical Subject Headings (MeSH)