NXF2

Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene.[5][6][7]

NXF2
Identifiers
Aliases	NXF2, CT39, TAPL-2, TCP11X2, nuclear RNA export factor 2
External IDs	OMIM: 300315 MGI: 1933192 HomoloGene: 88604 GeneCards: NXF2
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 102,247,161 bp[1] End 102,326,719 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X E3|X 56.31 cM Start 134,944,526 bp[2] End 134,964,754 bp[2]
Gene ontology Molecular function • nucleic acid binding • RNA binding Cellular component • cytoplasm • nuclear RNA export factor complex • cell nucleus • nucleoplasm • cytosol Biological process • multicellular organism development • poly(A)+ mRNA export from nucleus • mRNA transport • RNA transport • mRNA export from nucleus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56001	83454
Ensembl	ENSG00000269405	ENSMUSG00000009941
UniProt	Q9GZY0	n/a
RefSeq (mRNA)	NM_022053 NM_001039910 NM_017809	NM_001289735 NM_001289736 NM_031259
RefSeq (protein)	NP_071336 NP_001093156	n/a
Location (UCSC)	Chr X: 102.25 – 102.33 Mb	Chr X: 134.94 – 134.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene.[7]

Interactions

NXF2 has been shown to interact with NUP214.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000269405 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009941 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553. PMID 11073998.
6. Wang PJ, McCarrey JR, Yang F, Page DC (Apr 2001). "An abundance of X-linked genes expressed in spermatogonia". Nature Genetics. 27 (4): 422–426. doi:10.1038/86927. PMID 11279525.
7. "Entrez Gene: NXF2 nuclear RNA export factor 2".

Further reading

• Black BE, Lévesque L, Holaska JM, Wood TC, Paschal BM (Dec 1999). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Molecular and Cellular Biology. 19 (12): 8616–24. doi:10.1128/MCB.19.12.8616. PMC 84993. PMID 10567585.
• Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P, Froyen G (Sep 2001). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Current Biology. 11 (18): 1381–1391. doi:10.1016/S0960-9822(01)00419-5. PMID 11566096.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.