NKTR

NK-tumor recognition protein is a protein that in humans is encoded by the NKTR gene.[5][6][7]

NKTR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HE9
Identifiers
Aliases	NKTR, p104, natural killer cell triggering receptor
External IDs	OMIM: 161565 MGI: 97346 HomoloGene: 122148 GeneCards: NKTR
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 42,600,655 bp[1] End 42,648,735 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F4|9 72.57 cM Start 121,719,169 bp[2] End 121,756,843 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • isomerase activity • peptidyl-prolyl cis-trans isomerase activity • cyclosporin A binding • unfolded protein binding Cellular component • membrane • nucleoplasm • mitochondrion • cytosol • cell membrane • cell nucleus Biological process • protein folding • protein peptidyl-prolyl isomerization • protein refolding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4820	18087
Ensembl	ENSG00000114857	ENSMUSG00000032525
UniProt	P30414	P30415
RefSeq (mRNA)	NM_001012651 NM_005385 NM_001349124 NM_001349125 NM_001349126	NM_010918
RefSeq (protein)	NP_005376 NP_001336053 NP_001336054 NP_001336055	NP_035048
Location (UCSC)	Chr 3: 42.6 – 42.65 Mb	Chr 9: 121.72 – 121.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000114857 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032525 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Young HA, Jenkins NA, Copeland NG, Simek S, Lerman MI, Zbar B, Glenn G, Ortaldo JR, Anderson SK (Jul 1993). "Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9". Genomics. 16 (2): 548–549. doi:10.1006/geno.1993.1229. PMID 8314596.
6. Chambers CA, Gallinger S, Anderson SK, Giardina S, Ortaldo JR, Hozumi N, Roder J (May 1994). "Expression of the NK-TR gene is required for NK-like activity in human T cells". J Immunol. 152 (6): 2669–74. PMID 8144875.
7. "Entrez Gene: NKTR natural killer-tumor recognition sequence".

Further reading

• Frey JL, Bino T, Kantor RR, et al. (1992). "Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes". J. Exp. Med. 174 (6): 1527–1536. doi:10.1084/jem.174.6.1527. PMC 2119033. PMID 1720812.
• Rinfret A, Anderson SK (1993). "IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism". Mol. Immunol. 30 (14): 1307–1313. doi:10.1016/0161-5890(93)90047-F. PMID 8413330.
• Anderson SK, Gallinger S, Roder J, et al. (1993). "A cyclophilin-related protein involved in the function of natural killer cells". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 542–546. doi:10.1073/pnas.90.2.542. PMC 45699. PMID 8421688.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–1187. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Davis TL, Walker JR, Campagna-Slater V, et al. (2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLOS Biol. 8 (7): e1000439. doi:10.1371/journal.pbio.1000439. PMC 2911226. PMID 20676357.