NET1

Neuroepithelial cell-transforming gene 1 protein is a protein that in humans is encoded by the NET1 gene.[5][6]

NET1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EO2, 4XH9
Identifiers
Aliases	NET1, ARHGEF8, NET1A, neuroepithelial cell transforming 1
External IDs	OMIM: 606450 MGI: 1927138 HomoloGene: 4283 GeneCards: NET1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.1 Start 5,412,557 bp[1] End 5,459,056 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 3,882,018 bp[2] End 3,918,220 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GTP-Rho binding • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • GO:0001948 protein binding Cellular component • cytoplasm • cytosol • cell membrane • cell nucleus • intracellular Biological process • cellular response to ionizing radiation • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • myoblast migration • positive regulation of substrate adhesion-dependent cell spreading • regulation of Rho protein signal transduction • GO:0007243 intracellular signal transduction • regulation of small GTPase mediated signal transduction • regulation of cell growth • signal transduction • cellular response to hydrogen peroxide • positive regulation of apoptotic process • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10276	56349
Ensembl	ENSG00000173848	ENSMUSG00000021215
UniProt	Q7Z628 Q5SQI7	Q9Z206
RefSeq (mRNA)	NM_001047160 NM_005863	NM_001047159 NM_019671
RefSeq (protein)	NP_001040625 NP_005854 NP_005854.2	NP_001040624 NP_062645
Location (UCSC)	Chr 10: 5.41 – 5.46 Mb	Chr 13: 3.88 – 3.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000173848 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021215 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chan AM, Takai S, Yamada K, Miki T (Jul 1996). "Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning". Oncogene. 12 (6): 1259–66. PMID 8649828.
6. "Entrez Gene: NET1 neuroepithelial cell transforming gene 1".

Further reading

• Shen X, Li J, Hu PP, et al. (2001). "The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation". J. Biol. Chem. 276 (18): 15362–8. doi:10.1074/jbc.M009534200. PMID 11278519.
• Dobrosotskaya IY (2001). "Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1". Biochem. Biophys. Res. Commun. 283 (4): 969–75. doi:10.1006/bbrc.2001.4880. PMID 11350080.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Qin H, Carr HS, Wu X, et al. (2005). "Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1". J. Biol. Chem. 280 (9): 7603–13. doi:10.1074/jbc.M412141200. PMID 15611121.
• Alberts AS, Qin H, Carr HS, Frost JA (2005). "PAK1 negatively regulates the activity of the Rho exchange factor NET1". J. Biol. Chem. 280 (13): 12152–61. doi:10.1074/jbc.M405073200. PMID 15684429.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Leyden J, Murray D, Moss A, et al. (2006). "Net1 and Myeov: computationally identified mediators of gastric cancer". Br. J. Cancer. 94 (8): 1204–12. doi:10.1038/sj.bjc.6603054. PMC 2361249. PMID 16552434.
• García-Mata R, Dubash AD, Sharek L, et al. (2007). "The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity". Mol. Cell. Biol. 27 (24): 8683–97. doi:10.1128/MCB.00157-07. PMC 2169424. PMID 17938206.

External links

• NET1 human gene location in the UCSC Genome Browser.
• NET1 human gene details in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Neuroepithelial cell-transforming gene 1 protein (NET1)