NECAP2

Adaptin ear-binding coat-associated protein 2 is a protein that in humans is encoded by the NECAP2 gene.[5][6][7]

NECAP2
Identifiers
Aliases	NECAP2, NECAP endocytosis associated 2
External IDs	OMIM: 611624 MGI: 1913397 HomoloGene: 9168 GeneCards: NECAP2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 16,440,721 bp[1] End 16,460,078 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 141,066,512 bp[2] End 141,078,357 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55707	66147
Ensembl	ENSG00000157191	ENSMUSG00000028923
UniProt	Q9NVZ3	Q9D1J1
RefSeq (mRNA)	NM_001145277 NM_001145278 NM_018090	NM_025383
RefSeq (protein)	NP_001138749 NP_001138750 NP_060560	NP_079659
Location (UCSC)	Chr 1: 16.44 – 16.46 Mb	Chr 4: 141.07 – 141.08 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

NECAP2 has been shown to interact with AP1G1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000157191 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028923 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ritter B, Philie J, Girard M, Tung EC, Blondeau F, McPherson PS (Oct 2003). "Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif". EMBO Rep. 4 (11): 1089–95. doi:10.1038/sj.embor.embor7400004. PMC 1326374. PMID 14555962.
6. Ritter B, Blondeau F, Denisov AY, Gehring K, McPherson PS (Oct 2004). "Molecular mechanisms in clathrin-mediated membrane budding revealed through subcellular proteomics". Biochem. Soc. Trans. 32 (Pt 5): 769–73. doi:10.1042/BST0320769. PMID 15494011.
7. "Entrez Gene: NECAP2 NECAP endocytosis associated 2".
8. Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J. Biol. Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (2000). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J. Biol. Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.