NDRG4

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene.[5][6][7]

NDRG4
Identifiers
Aliases	NDRG4, BDM1, SMAP-8, SMAP8, NDRG family member 4
External IDs	OMIM: 614463 MGI: 2384590 HomoloGene: 23228 GeneCards: NDRG4
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 58,462,846 bp[1] End 58,513,628 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D1 Start 95,676,980 bp[2] End 95,715,119 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • molecular function Cellular component • cytosol • basolateral plasma membrane • cell projection membrane • cytoplasm • mitochondrion • endoplasmic reticulum membrane Biological process • visual learning • negative regulation of platelet-derived growth factor receptor signaling pathway • cell migration involved in heart development • cell differentiation • negative regulation of smooth muscle cell proliferation • regulation of endocytic recycling • negative regulation of smooth muscle cell migration • cardiac muscle cell proliferation • embryonic heart tube development • heart looping • cell growth • vesicle docking • positive regulation of ERK1 and ERK2 cascade • positive regulation of neuron projection development • brain development • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	65009	234593
Ensembl	ENSG00000103034	ENSMUSG00000036564
UniProt	Q9ULP0	Q8BTG7
RefSeq (mRNA)	NM_001130487 NM_001242833 NM_001242834 NM_001242835 NM_001242836 NM_020465 NM_022910 NM_001363869	NM_001195006 NM_145602
RefSeq (protein)	NP_001123959 NP_001229762 NP_001229763 NP_001229764 NP_001229765 NP_065198 NP_075061 NP_001350798 NP_001365261 NP_001365262 NP_001365263 NP_001365264 NP_001365265 NP_001365266 NP_001365267 NP_001365268 NP_001365269 NP_001365270 NP_001365271 NP_001365272 NP_001365273 NP_001365274 NP_001365275 NP_001365276	NP_001181935 NP_663577 NP_001359350 NP_001359352 NP_001359354 NP_001359355 NP_001359356 NP_001359357 NP_001359358 NP_001359359 NP_001359360 NP_001359361 NP_001359362 NP_001359363 NP_001359364
Location (UCSC)	Chr 16: 58.46 – 58.51 Mb	Chr 8: 95.68 – 95.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000103034 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036564 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T (May 2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
6. Hongo S, Watanabe T, Takahashi K, Miyazaki A (Apr 2006). "Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation". J Cell Biochem. 98 (1): 185–93. doi:10.1002/jcb.20763. PMID 16408304. S2CID 10192022.
7. "Entrez Gene: NDRG4 NDRG family member 4".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol. Cell. Biochem. 229 (1–2): 35–44. doi:10.1023/A:1017934810825. PMID 11936845. S2CID 24226208.
• Ohki T, Hongo S, Nakada N, et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". Brain Res. Dev. Brain Res. 135 (1–2): 55–63. doi:10.1016/S0165-3806(02)00300-0. PMID 11978393.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nishimoto S, Tawara J, Toyoda H, et al. (2003). "A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells". Eur. J. Biochem. 270 (11): 2521–31. doi:10.1046/j.1432-1033.2003.03626.x. PMID 12755708.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.