Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.53, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, ADPRibase-Mn) is an enzyme with systematic name CDP-choline phosphohydrolase.[1][2] This enzyme catalyses the following chemical reaction
- (1) CDP-choline + H2O CMP + phosphocholine
- (2) ADP-ribose + H2O AMP + D-ribose 5-phosphate
| Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.1.53 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme requires Mn2+, which cannot be replaced by Mg2+.
References
- Canales J, Pinto RM, Costas MJ, Hernández MT, Miró A, Bernet D, Fernández A, Cameselle JC (January 1995). "Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg(2+)-and/or Mn(2+)-dependent hydrolases acting on ADP-ribose". Biochimica et Biophysica Acta. 1246 (2): 167–77. doi:10.1016/0167-4838(94)00191-i. PMID 7819284.
- Canales J, Fernández A, Ribeiro JM, Cabezas A, Rodrigues JR, Cameselle JC, Costas MJ (July 2008). "Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells" (PDF). The Biochemical Journal. 413 (1): 103–13. doi:10.1042/bj20071471. PMID 18352857.
External links
- Mn2+-dependent+ADP-ribose/CDP-alcohol+diphosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)
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