Methionine S-methyltransferase
In enzymology, a methionine S-methyltransferase (EC 2.1.1.12) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + L-methionine S-adenosyl-L-homocysteine + S-methyl-L-methionine
| methionine S-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.12 | ||||||||
| CAS number | 9027-77-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and L-methionine, whereas its two products are S-adenosylhomocysteine and S-methyl-L-methionine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:L-methionine S-methyltransferase. Other names in common use include S-adenosyl methionine:methionine methyl transferase, methionine methyltransferase, S-adenosylmethionine transmethylase, and S-adenosylmethionine-methionine methyltransferase. This enzyme participates in selenoamino acid metabolism. It has 2 cofactors: manganese, and zinc.
References
- Karr D, Tweto J, Albersheim P (1967). "S-adenosyl methionine: methionine methyl transferase from wheat germ". Arch. Biochem. Biophys. 121 (3): 732–8. doi:10.1016/0003-9861(67)90061-6. PMID 6078098.