Matthias Tschöp

Matthias H. Tschöp (born April 7, 1967) is a German physician and scientist. He is the Chief Executive Officer and Scientific Director of Helmholtz Zentrum München, German Research Center for Environmental Health. He is also Alexander von Humboldt Professor[1] and Chair of Metabolic Diseases at Technical University of Munich and serves as an adjunct Professor at Yale University.

Matthias Tschöp
Born (1967-04-07) April 7, 1967
Munich, Germany
NationalityGerman
EducationLudwig Maximilian University of Munich
Known forNovel drug candidates for diabetes and obesity based on gut-brain signals
AwardsPaul Langerhans Medal (2019); Carus Medal (2017); Hansen Family Award (2017); Erwin Schrödinger Prize (2014); Paul Martini Prize (2014); Outstanding Scientific Achievement Award, American Diabetes Association (2011); Scientific Achievement Award, The Obesity Society (2007)
Scientific career
InstitutionsHelmholtz Zentrum München; Technical University of Munich

Career and research

Matthias Tschöp obtained an M.D. from the Ludwig Maximilian University of Munich (1993) where he worked as a clinician (1994-1998) in neuroendocrinology before accepting a research fellowship at the Eli Lilly Discovery Research Laboratories (1999-2002) and leading a research team at the German Institute of Human Nutrition (Potsdam/Nuthetal 2002-2003). He served as a Professor of Endocrinology and Diabetes at the Metabolic Diseases Institute of the University of Cincinnati (2003-2009), before being named the Arthur Russell Morgan Endowed Chair of Medicine, and Research Director of the Metabolism Center of Excellence for Diabetes and Obesity at the University of Cincinnati (2009-2011).[2] He was Research Director of the Helmholtz Diabetes Center and Director of the Institute for Diabetes and Obesity at Helmholtz Zentrum München (2011-2018). Since 2020, he is a member of the Cell Advisory Board.

Early in his career, Tschöp reported on the orexigenic, adipogenic, and metabolic effects of ghrelin and its secretory control by nutrients, which has had a major influence on human obesity and diabetes research. His corresponding publication in Nature is among today's most frequently cited metabolism research papers.[3] It added a fundamental pathway to the current model of body weight and glucose control and established novel drug targets for metabolic diseases. Tschöp went on to further dissect gut-brain communication pathways, based on GI-hormone signaling and lessons from unraveling the molecular underpinnings of gastric bypass surgery.

Together with his close collaborator Richard DiMarchi (Indiana University)[4] he discovered and validated novel gut hormone co-agonist peptides, which simultaneously target several neuroendocrine receptors and efficiently reduce body weight and improve glucose tolerance. Several of these compounds are now in clinical trials for the treatment of diabetes and obesity. Tschöp and DiMarchi more recently went on to discover and validate another class of drug candidates by engineering peptide to deliver steroid/small molecules to selected cell populations.[5]

Awards and recognition
  • 2020: Member of the European Molecular Biology Organization (EMBO)
  • 2019: C. Ronald Kahn Distinguished Lectureship 2019-2020, Joslin Diabetes Center
  • 2019: Paul Langerhans Medal[6]
  • 2018: Carus Prize, City of Schweinfurt
  • 2018: Ordinary member of the Bavarian Academy of Sciences and Humanities[7]
  • 2017: Carus Medal, Academy of Sciences Leopoldina[8]
  • 2017: Charles H. Best Lectureship and Award, University of Toronto[9]
  • 2017: Hansen Family Award, Bayer Foundations[10]
  • 2017: Honorary doctorate degree (Dr. h.c.), University of Leipzig
  • 2017: Rolf Sammet Professorship, Frankfurt University
  • 2017: Outstanding Innovation Award, Endocrine Society[11]
  • 2017: Geoffrey Harris Prize
  • 2016: The Victor Mutt Award
  • 2016: European Medal of the Society for Endocrinology
  • 2016: Elected Member, Academia Europaea
  • 2016: ERC Advanced Grant
  • 2014: Erwin Schrödinger Prize, Stifterverband Science Award - Erwin Schrödinger Prize[12][13]
  • 2014: Paul Martini Prize, Paul Martini Foundation[14]
  • 2014: Linda and Jack Gill Distinguished Scientist Award, Linda and Jack Gill Center for Biomolecular Science at Indiana University[15]
  • 2013: Elected Member, German National Academy of Sciences Leopoldina[16]
  • 2012: Werner-Creutzfeld-Award, German Diabetes Society
  • 2012: Alexander von Humboldt Professorship, Alexander von Humboldt Foundation
  • 2011: Outstanding Scientific Achievement Award, American Diabetes Association[17]
  • 2010: NIH/NIDDK 60th Anniversary Scholar Award[18]
  • 2010: André Mayer Award, Int. Association for the Study of Obesity, IASO
  • 2009: Elected Member, The American Society for Clinical Investigation, ASCI
  • 2007: Scientific Achievement Award, The Obesity Society, TOS/NAASO
  • 2007: Christina Barz Award of the German Society for Psychiatry, Neurology and Psychosomatic Medicine
  • 2002: Young Investigator Award, European Neuroendocrine Association, ENEA
  • 2001: Schoeller-Junkmann Award of the German Endocrine Society, DGE
  • 2000: Lilly Research Laboratories President's Award
  • 2000: Eli Lilly Endocrine Research Award for Science

References
  1. Award winners 2012: Prof. Dr. Matthias Tschöp. humboldt-professur.de. Retrieved on 2014-01-15.
  2. American Society for Clinical Investigation (ASCI). the-asci.org. Retrieved on 2015-01-22.
  3. Tschöp, Matthias; Smiley, David L.; Heiman, Mark L. (2000). "Ghrelin induces adiposity in rodents". Nature. 407 (6806): 908–913. Bibcode:2000Natur.407..908T. doi:10.1038/35038090. PMID 11057670. S2CID 4564644.
  4. Claiborn, Kathryn (2011). "Masters of metabolism: Matthias Tschöp and Richard di Marchi". Journal of Clinical Investigation. 121 (8): 2952. doi:10.1172/JCI59886. PMC 3148758.
  5. Gruber, Karl (2015). "Moving towards a more precise treatment of diabetes". The Lancet Diabetes & Endocrinology. 3 (3): 171. doi:10.1016/S2213-8587(15)00010-8. PMID 25702247.
  6. Matthias Tschoep receives the highest honor from the German Diabetes Association. www.dzd-ev.de/en. Retrieved on 2019-06-07.
  7. Matthias Tschöp receives Bavarian honor. tum.de. Retrieved on 2019-11-04.
  8. DZD Scientist Matthias Tschöp to Receive Carus Medal. dzd-ev.de. Retrieved on 2019-11-07.
  9. Charles H. Best Lectureship and Award. physiology.utoronto.ca. Retrieved on 2017-12-25.
  10. "Prestigious award from the Bayer Science & Education Foundation: 2017 Hansen Family Award goes to Professor Jens Brüning and Professor Matthias H. Tschöp". Archived from the original on 2017-06-06. Retrieved on 2017-12-25.
  11. Daniel J. Drucker, MD (Jan 2017). Meet the 2017 Laureates: Matthias Tschöp, MD. endocrinenews.endocrine.org. Retrieved on 2017-12-25.
  12. Erwin Schrödinger Preis goes to Helmholtz Zentrum München. Archived 2015-02-09 at the Wayback Machine helmholtz-muenchen.de. Retrieved on 2015-01-15.
  13. Moore, Charles (December 10, 2014). ‘Unparalleled’ Results In Animal Trials Treatment To Cure Adult-onset Diabetes, Obesity. diabetesnewsjournal.com. Retrieved on 2015-02-15.
  14. Paul Martini Prize: Award for new approaches in the treatment of diabetes and obesity. Archived 2016-03-04 at the Wayback Machine paul-martini-stiftung.de. Retrieved on 2015-01-14.
  15. Gill Symposium honors two neuroscientists for work on the brain's role in regulating metabolism. archive.news.indiana.edu. Retrieved on 2019-11-07.
  16. Prof. Dr. Matthias Tschöp. leopoldina.org. Retrieved on 2015-01-14.
  17. "American Diabetes Association Honors UC Researcher With Scientific Achievement Award". Archived from the original on 2018-01-06. Retrieved 2018-01-05.
  18. "Tschöp to Receive NIDDK Scholar Award". Archived from the original on 2018-01-06. Retrieved 2018-01-05.

Prof. Matthias Tschöp (2012-05-16). Medicine: Prof. Matthias Tschöp. Alexander von Humboldt Foundation.

Prof. Matthias Tschöp, Chair of Metabolic Diseases, TUM School of Medicine

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