Matthew P. Hardy

Matthew Phillip Hardy (1957-2007) was an American reproductive biologist who has made fundamental contributions in Leydig cell differentiation and function.[1]

Matthew P. Hardy
Born1957
Evanston, Illinois, United States
DiedNovember 4, 2007
New York City, United States
Alma materUniversity of Virginia
Spouse(s)Dianne O. Hardy
Scientific career
Fieldsreproductive biology

Biography

M. P. Hardy was born in Evanston, Illinois, completed elementary education at the Sidwell Friends School in Washington, DC. He received a double bachelor's degree in biology and philosophy from Oberlin College in 1979, and received a Ph.D. in Biology at the University of Virginia in 1985. Then Hardy conducted postdoctoral work with Larry L. Ewing at The Johns Hopkins School of Hygiene and Public Health.[2] In 1990, he joined the Population Council, and became a Senior Scientist several years later.[1]

Hardy's research focus on the origin and development of Leydig cells in the adult mammalian testis, which from stem Leydig cells (SLC) to progenitor Leydig cells (PLC) to immature Leydig cells (ILC) and finally to adult Leydig cells (ALC). He identified this sequence in detail in morphological, physiological, biochemical and molecular methodologies.[3] He also revealed the role of luteinizing hormone (LH) in the androgenesis of adult Leydig cells.[1]

He died suddenly after accomplishing the 2007 New York City Marathon.[1]

References
  1. Barry R Zirkin; Peter Schlegel; Bernard Robaire; Sally Perreault (2008). "In Memoriam Matthew P. Hardy, Ph.D. 1957–2007". Biology of Reproduction. 78 (3): 563–564. doi:10.1095/biolreprod.108.067983.
  2. Matthew P Hardy; Barry R Zirkin; Larry L Ewing (1989). "Kinetic studies on the development of the adult population of Leydig cells in testes of the pubertal rat". Endocrinology. 142 (2): 762–70. doi:10.1210/endo-124-2-762. PMID 2912699.
  3. Dong L, Jelinsky SA, Finger JN, Johnston DS, Kopf GS, Sottas CM, Hardy MP, Ge RS (December 2007). "Gene expression during development of fetal and adult Leydig cells". Annals of the New York Academy of Sciences. 1120 (1): 16–35. doi:10.1196/annals.1411.016. PMID 18184909.


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