Mary Kay Lobo

Mary Kay Lobo (born 1975) is an American psychiatric neuroscientist who is a Professor of Neurobiology at the University of Maryland School of Medicine. Her research considers the molecular mechanisms that underpin drug addiction and depression. She was named a finalist in the 2011 Blavatnik Awards for Young Scientists.

Mary Kay Lobo
Born1975 (age 45–46)
Alma materUniversity of California, Los Angeles
Scientific career
InstitutionsUniversity of Maryland School of Medicine
ThesisGenetic analyses of striatal projection neuron subtypes in the direct and indirect pathways (2007)

Early life and education

Lobo was born and raised in Los Angeles. She studied biology and anthropology at the University of California, Los Angeles. She stayed in California for her doctoral research, where she completed genetic analysis of neuron subtypes. To achieve this, she had to develop a novel methodology for isolating the main striatal projection neuron subtypes ([medium spiny neuron]]s). These two neuron play opposite but complimentary roles in neural circuitry.[1] She worked in the laboratory of X. William Yang in the David Geffen School of Medicine at UCLA. Lobo was a postdoctoral researcher at the University of Texas Southwestern Medical Center where she worked in the laboratory of Eric J. Nestler.

Research and career

In 2011 Lobo was appointed to the faculty at the University of Maryland School of Medicine.[2] She has continued to make use of genetic analysis to understand how neuronal circuits are involved with drug addiction and depression.[1] In such scenarios, the circuits become dysfunctional, influencing downstream brain region.[1] By combining genetic analysis with optogenetic, Lobo has identified divergent roles in nucleus accumbens projection neurons in the brain's reward centre.[1] She showed that the molecular regulator of mitochondrial fission is amplified in the brain reward regions of individuals dependent on cocaine, and that blocking this fission process can reduce cocaine-seeking behaviour.[2]

Lobo investigated effective medications and molecular targets for major depressive disorders.[3] To achieve this, she uses mouse models of depression. She showed that chronic stress decreases the number of dendrites and size of nerve cells in mice, which limits the number of connections with nearby nerve cells.[3][4] She proposed that the small transforming protein RhoA, which is involved the maintenance of dendrite shape and size, and its molecular target rho-associated protein kinase (ROCK), offer hope for the restoration of brain function in people with major depressive disorders.[3] The use of RhoA inhibitors can result in antidepressant like responses to stress.[3]

Academic service

Lobo was made associate editor of The Journal of Neuroscience in 2014.[5] She serves on the Editorial Board of ACS Chemical Neuroscience and Biological Psychiatry.[6][7]

Awards and honors

Selected publications
  • Chaudhury, Dipesh; Walsh, Jessica J.; Friedman, Allyson K.; Juarez, Barbara; Ku, Stacy M.; Koo, Ja Wook; Ferguson, Deveroux; Tsai, Hsing-Chen; Pomeranz, Lisa; Christoffel, Daniel J.; Nectow, Alexander R. (2013). "Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons". Nature. 493 (7433): 532–536. doi:10.1038/nature11713. ISSN 1476-4687. PMC 3554860.
  • Lobo, Mary Kay; Covington, Herbert E.; Chaudhury, Dipesh; Friedman, Allyson K.; Sun, HaoSheng; Damez-Werno, Diane; Dietz, David M.; Zaman, Samir; Koo, Ja Wook; Kennedy, Pamela J.; Mouzon, Ezekiell (2010-10-15). "Cell Type–Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward". Science. 330 (6002): 385–390. doi:10.1126/science.1188472. ISSN 0036-8075. PMC 3011229. PMID 20947769.
  • Covington, Herbert E.; Lobo, Mary Kay; Maze, Ian; Vialou, Vincent; Hyman, James M.; Zaman, Samir; LaPlant, Quincey; Mouzon, Ezekiel; Ghose, Subroto; Tamminga, Carol A.; Neve, Rachael L. (2010-12-01). "Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex". Journal of Neuroscience. 30 (48): 16082–16090. doi:10.1523/JNEUROSCI.1731-10.2010. ISSN 0270-6474. PMID 21123555.

References
  1. "Mary Kay Lobo | Blavatnik Awards for Young Scientists". blavatnikawards.org. Retrieved 2021-01-09.
  2. "#IAmNYAS: Mary Kay Lobo, PhD". New York Academy of Sciences. 2018-04-26.
  3. "Developing Better Treatments for Depression: Dr. Mary Kay Lobo". One Mind. 2018-04-23. Retrieved 2021-01-09.
  4. "Specific Gene Could Play Key Role in Depression". Psychiatry & Behavioral Health Learning Network. Retrieved 2021-01-09.
  5. "Editorial Board | Journal of Neuroscience". www.jneurosci.org. Retrieved 2021-01-09.
  6. Biological Psychiatry Editorial Board.
  7. "Editorial Board". pubs.acs.org. Retrieved 2021-01-09.
  8. "One Mind - IMHRO: Opening up discussions on brain health". Research Features. 2016-10-31. Retrieved 2021-01-09.
  9. "NIMH » Two NIMH Grantees Receive Prestigious Presidential Award". www.nimh.nih.gov. Retrieved 2021-01-09.
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