Marcel R.M. van den Brink

Marcel R.M. van den Brink (born November 14, 1960) is a Dutch hematologist and researcher at Memorial Sloan Kettering Cancer Center known for his research in hematopoietic stem cell transplantation for cancer patients.[1]

Marcel R.M. van den Brink
BornNovember 14, 1960
Oegstgeest, Netherlands
Alma materUniversity of Leiden, Netherlands
Spouse(s)Lia Palomba, MD
ChildrenLucas van den Brink, Alessandro van den Brink
Scientific career
Fieldshematology, oncology, immunology
InstitutionsMemorial Sloan Kettering Cancer Center, Sloan Kettering Institute, Weill Graduate School of Medical Sciences

Career

van den Brink obtained his M.D. and Ph.D. from the University of Leiden, completed a postdoctoral fellowship at the Pittsburgh Cancer Institute in Pittsburgh, PA and residency at Duke University Medical Center in Durham, NC. From 1994 to 1997, van den Brink was a Clinical Fellow in Hematology and Oncology at Beth Israel Deaconess Medical Center and a Clinical Fellow in Medicine at Harvard Medical School in Boston, MA. He then carried out a post-doctoral fellowship at the Dana Farber Cancer Institute in Boston, MA from 1995 to 1999.

He is now the Head of the Division of Hematologic Malignancies[2] and Alan Houghton Chair in Immunology[3] at Memorial Sloan Kettering Cancer Center (MSKCC), as well as Professor at Gerstner Sloan Kettering Graduate School of Biomedical Sciences[4] and Weill Cornell Graduate School of Medical Sciences. He is the Co-Director[5] of the Parker Institute for Cancer Immunotherapy.[6] He is also chairman of DKMS Stiftung Leben Spenden.[7]

Research

As a physician-scientist, van den Brink studies allogeneic bone marrow transplantation both in the clinic and the laboratory. Areas in which van den Brink has published research include the development of strategies to enhance post-transplant immune reconstitution;[8] the pathophysiology of graft-versus-host disease[9] (GVHD), and intestinal microflora.[10]

Awards

Selected publications
  • Tsai JJ, Takahashi K, Dudakov JA, Shieh J, Singer NV, West ML, Smith OM, Young LF, Holland AM, Shono Y, Ghosh A, Tran HT, Moore MAS, van den Brink MRM. "Nrf2 regulates haematopoietic stem cell function". Nature Cell Biology. 2013; 15(3): 309-16. PMID 23434824; PMC 3699879.
  • Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Liu C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MRM. "IL-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft vs. host disease". Immunity. 2012; 37:339-350. (Previews in Immunity 2012; 37:196). PMID 22921121; PMC 3477611.
  • Jenq RR, Ubeda C, Taur Y, Menezes CC, Khanin R, Dudakov JA, Liu C, West ML, Singer NV, Equinda MJ, Gobourne A, Lipuma L, Young LF, Smith OM, Ghosh S, Hanash AM, Goldberg JD, Aoyama K, Blazar BR, Pamer EG, van den Brink MRM. "Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation". Journal of Experimental Medicine. 2012; 209:903-911. (Research Highlight in Nature Reviews Immunology 2012; 12:399) PMID 22547653; PMC 3348096.
  • Dudakov JA, Hanash AM, Jenq RR, Young LF, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL, van den Brink MRM. "IL-22 drives endogenous thymic regeneration in mice". Science. 2012; 336:91-95. (Perspectives in Science 2012; 336:40; Leading Edge Select in Cell 2012; 149:729) PMID 22383805; PMC 3616391.
  • Zakrzewski JL, Suh D, Markley JC, Smith OM, King C, Goldberg GL, Jenq R. Holland AM, Grubin J, Cabrera-Perez J, Brentjens RJ, Lu SX, Rizzuto G, Sant'Angelo DB, Riviere I, Sadelain M, Heller G, Zuniga-Pflucker JC, Liu C, van den Brink MRM. "Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors". Nature Biotechnology 2008; 4:453-461. (commentary in Nature Reviews in Immunology 2008; 8:321) PMID 18376399; PMC 2731996.
  • Zakrzewski JL, Kochman AA, Lu SX, Terwey TH, Kim TD, Hubbard VM, Muriglan SJ, Suh D, Cabrera-Perez J, Radhakrishnan R, Heller G, Zuniga-Pflucker JC, Alpdogan O, van den Brink MRM. "Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation". Nature Medicine 2006; 12:1039-1047. PMID 16936725.
  • Schmaltz C, Alpdogan O, Kappel BJ, Muriglan SJ, Rotolo JA, Ongchin J, Willis LM, Greenberg AS, Eng JM, Crawford JM, Murphy GF, Yagita H, Walczak H, Peschon J, van den Brink MRM. "T cells require TRAIL for optimal graft-versus-tumor activity". Nature Medicine 2002; 8:1433-1437. PMID 12426560.

References
  1. "Marcel R.M. van den Brink". stemcell.ny. Retrieved 25 October 2019.
  2. "Marcel R.M. van den Brink". Memorial Sloan Kettering Cancer Center. Retrieved 2019-10-25.
  3. “Alan Houghton Chair”, On Cancer, News and Insights from Memorial Sloan Kettering, March 21, 2008.
  4. "Marcel van den Brink". Gerstner Sloan Kettering Graduate School of Biomedical Sciences. Retrieved 2019-10-25.
  5. “A Talk with MSK's Parker Institute Co-Director” , News and Insights from Memorial Sloan Kettering.
  6. "Marcel van den Brink, MD, PhD". Parker Institute for Cancer Immunotherapy. Retrieved 2019-10-24.
  7. "Mechtild Harf Research Grant becomes John Hansen Research Grant". www.dkms.org. 2019-10-22. Retrieved 2019-10-24.
  8. “Manipulating immune function and thymus recovery” Marcel van den Brink Lab.
  9. "Study reveals gut microbes may help protect people having a bone marrow transplant". medicalxpress.com. Retrieved 2019-10-25.
  10. “Microorganisms in the Gut Can Affect Cancer Outcomes” On Cancer, News and Insights from Memorial Sloan Kettering, August 11, 2016.
  11. BeTheMatch.org (2019-04-22). "Supporting researchers for post-transplant study". bethematch.org. Retrieved 2019-10-25.
  12. "Scholars: Current and Former Awardees". Damon Runyon. Retrieved 2019-10-25.
  13. "The American Society for Clinical Investigation". Retrieved 2019-10-25.
  14. "EFIS – European Federation of Immunological Societies: EFIS-IL Lecture Award". www.efis.org. Retrieved 2019-10-25.
  15. "9th Annual Delete Blood Cancer Gala Evening to Be Hosted by Randy Jackson". www.businesswire.com. 2015-03-09. Retrieved 2019-10-25.
  16. "Lectureship Awards - CTTC". www.cttcanada.org. Retrieved 2019-10-25.
  17. "Marcel van den Brink". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 2 May 2020.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.