MYL6B

Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene.[5][6][7]

MYL6B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OE9, 1W7I, 1W7J
Identifiers
Aliases	MYL6B, MLC1SA, myosin light chain 6B
External IDs	OMIM: 609930 MGI: 1917789 HomoloGene: 86887 GeneCards: MYL6B
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 56,152,256 bp[1] End 56,159,647 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,494,157 bp[2] End 128,498,685 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • structural constituent of muscle • cellular motor activity • GO:0001948 protein binding Cellular component • cytosol • muscle myosin complex • unconventional myosin complex • extracellular exosome • myosin complex Biological process • muscle contraction • skeletal muscle tissue development • muscle filament sliding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140465	216459
Ensembl	ENSG00000196465	ENSMUSG00000039824
UniProt	P14649	Q8CI43
RefSeq (mRNA)	NM_002475 NM_001199629	NM_172259
RefSeq (protein)	NP_001186558 NP_002466	NP_758463
Location (UCSC)	Chr 12: 56.15 – 56.16 Mb	Chr 10: 128.49 – 128.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000196465 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039824 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zimmermann K, Starzinski-Powitz A (Feb 1990). "A novel isoform of myosin alkali light chain isolated from human muscle cells". Nucleic Acids Res. 17 (24): 10496. doi:10.1093/nar/17.24.10496. PMC 335321. PMID 2602161.
6. Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
7. "Entrez Gene: MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle".

Further reading

• Coureux PD, Sweeney HL, Houdusse A (2005). "Three myosin V structures delineate essential features of chemo-mechanical transduction". EMBO J. 23 (23): 4527–37. doi:10.1038/sj.emboj.7600458. PMC 533045. PMID 15510214.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition". J. Cell Sci. 109 (8): 2089–99. PMID 8856505.
• Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene. 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299.

External links

• Overview of all the structural information available in the PDB for UniProt: P14649 (Human Myosin light chain 6B (MYL6B)) at the PDBe-KB.