MYL1

Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.[5][6][7]

MYL1
Identifiers
Aliases	MYL1, MLC1F, MLC3F, myosin light chain 1, MYOFTA
External IDs	OMIM: 160780 MGI: 97269 HomoloGene: 23194 GeneCards: MYL1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q34 Start 210,290,150 bp[1] End 210,315,174 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 33.71 cM Start 66,924,295 bp[2] End 66,945,404 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • structural constituent of muscle Cellular component • contractile fiber • cytosol • muscle myosin complex • myofibril • sarcomere • myosin complex Biological process • muscle contraction • cardiac muscle contraction • muscle filament sliding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4632	17901
Ensembl	ENSG00000168530	ENSMUSG00000061816
UniProt	P05976	P05977
RefSeq (mRNA)	NM_079422 NM_079420	NM_001113387 NM_021285
RefSeq (protein)	NP_524144 NP_524146	NP_001106858 NP_067260
Location (UCSC)	Chr 2: 210.29 – 210.32 Mb	Chr 1: 66.92 – 66.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000168530 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061816 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
6. Cohen-Haguenauer O, Barton PJ, Nguyen VC, Serero S, Gross MS, Jegou-Foubert C, de Tand MF, Robert B, Buckingham M, Frezal J (Mar 1988). "Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter". Hum Genet. 78 (1): 65–70. doi:10.1007/BF00291237. PMID 3422212. S2CID 24782863.
7. "Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast".

Further reading

• Kelly RG, Buckingham ME (2000). "Modular regulation of the MLC1F/3F gene and striated muscle diversity". Microsc. Res. Tech. 50 (6): 510–21. doi:10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0.CO;2-1. PMID 10998640.
• Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene. 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299.
• Seidel U, Arnold HH (1989). "Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle". J. Biol. Chem. 264 (27): 16109–17. PMID 2777779.
• Seidel U, Bober E, Winter B, et al. (1987). "The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3". Nucleic Acids Res. 15 (12): 4989. doi:10.1093/nar/15.12.4989. PMC 305934. PMID 3601661.
• Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ (2001). "A Nonerythroid Isoform of Protein 4.1R Interacts with Components of the Contractile Apparatus in Skeletal Myofibers". Mol. Biol. Cell. 11 (11): 3805–17. doi:10.1091/mbc.11.11.3805. PMC 15038. PMID 11071908.
• Ballweber E, Galla M, Aktories K, et al. (2001). "Interaction of ADP-ribosylated actin with actin binding proteins". FEBS Lett. 508 (1): 131–5. doi:10.1016/S0014-5793(01)03040-X. PMID 11707283. S2CID 7241702.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.