MRVI1

Protein MRVI1 is a protein that in humans is encoded by the MRVI1 gene.[5][6]

IRAG1
Identifiers
Aliases	IRAG1, IRAG, JAW1L, murine retrovirus integration site 1 homolog, MRVI1, inositol 1,4,5-triphosphate receptor associated 1
External IDs	OMIM: 604673 MGI: 1338023 HomoloGene: 4425 GeneCards: IRAG1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 10,573,091 bp[1] End 10,693,988 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 57.9 cM Start 110,868,266 bp[2] End 110,982,461 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • perinuclear region of cytoplasm • integral component of membrane • platelet dense tubular network membrane • endoplasmic reticulum membrane • membrane • sarcoplasmic reticulum Biological process • blood coagulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10335	17540
Ensembl	ENSG00000072952	ENSMUSG00000005611
UniProt	Q9Y6F6	Q9WUX5
RefSeq (mRNA)	NM_130385 NM_001098579 NM_001100163 NM_001100167 NM_001206880 NM_001206881	NM_010826 NM_194464
RefSeq (protein)	NP_001092049 NP_001093633 NP_001093637 NP_001193809 NP_001193810 NP_569056	NP_034956 NP_919446
Location (UCSC)	Chr 11: 10.57 – 10.69 Mb	Chr 7: 110.87 – 110.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. Of the two characterized variants which encode different isoforms, one initiates translation at a non-AUG start site.[6]

Interactions

MRVI1 has been shown to interact with ITPR1[7] and PRKG1.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000072952 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005611 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shaughnessy JD, Largaespada DA, Tian E, Fletcher CF, Cho BC, Vyas P, Jenkins NA, Copeland NG (June 1999). "Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1". Oncogene. 18 (12): 2069–84. doi:10.1038/sj.onc.1202419. PMID 10321731.
6. "Entrez Gene: MRVI1 murine retrovirus integration site 1 homolog".
7. Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (March 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174. S2CID 205004996.
8. Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (June 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". J. Biol. Chem. 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393.

Further reading

• Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.
• Baltensperger K, Chiesi M, Carafoli E (1990). "Substrates of cGMP kinase in vascular smooth muscle and their role in the relaxation process". Biochemistry. 29 (41): 9753–60. doi:10.1021/bi00493a035. PMID 2271613.
• Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174. S2CID 205004996.
• Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". J. Biol. Chem. 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393.
• Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P, Hofmann F (2003). "Association of phospholamban with a cGMP kinase signaling complex". Biochem. Biophys. Res. Commun. 300 (1): 155–60. doi:10.1016/S0006-291X(02)02799-7. PMID 12480535.
• Fritsch RM, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselhöringer A, Hofmann F, Allescher HD (2004). "InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle". J. Biol. Chem. 279 (13): 12551–9. doi:10.1074/jbc.M313365200. PMID 14729908.
• Casteel DE, Boss GR, Pilz RB (2005). "Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif". J. Biol. Chem. 280 (46): 38211–8. doi:10.1074/jbc.M507021200. PMID 16166082.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Antl M, von Brühl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S, Schlossmann J (2007). "IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation". Blood. 109 (2): 552–9. doi:10.1182/blood-2005-10-026294. PMID 16990611.

External links

• MRVI1 human gene location in the UCSC Genome Browser.
• MRVI1 human gene details in the UCSC Genome Browser.