MOS (gene)

Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene.[5][6]

MOS
Identifiers
Aliases	MOS, MSV, v-mos Moloney murine sarcoma viral oncogene homolog, MOS proto-oncogene, serine/threonine kinase
External IDs	OMIM: 190060 MGI: 97052 HomoloGene: 3919 GeneCards: MOS
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q12.1 Start 56,112,942 bp[1] End 56,113,982 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A1|4 2.16 cM Start 3,870,657 bp[2] End 3,872,105 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • GO:0001948 protein binding • MAP kinase kinase kinase activity • ATP binding • kinase activity • protein serine/threonine kinase activity • signal transducer activity Cellular component • cytoplasm • cytosol Biological process • autophosphorylation • activation of MAPK activity • establishment of meiotic spindle orientation • chromatin organization • GO:0043147 meiotic spindle organization • phosphorylation • activation of MAPKK activity • MAPK cascade • GO:0007243 intracellular signal transduction • positive regulation of MAPK cascade • negative regulation of metaphase/anaphase transition of meiotic cell cycle • protein phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4342	17451
Ensembl	ENSG00000172680	ENSMUSG00000078365
UniProt	P00540	P00536
RefSeq (mRNA)	NM_005372	NM_020021
RefSeq (protein)	NP_005363	NP_064405
Location (UCSC)	Chr 8: 56.11 – 56.11 Mb	Chr 4: 3.87 – 3.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MOS (gene) has been shown to interact with MyoD.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000172680 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078365 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Singh B, Arlinghaus RB (May 1998). "Mos and the cell cycle". Prog Cell Cycle Res. 3: 251–9. doi:10.1007/978-1-4615-5371-7_20. ISBN 978-1-4613-7451-0. PMID 9552420.
6. "Entrez Gene: MOS v-mos Moloney murine sarcoma viral oncogene homolog".
7. Lenormand, J L; Benayoun B; Guillier M; Vandromme M; Leibovitch M P; Leibovitch S A (Feb 1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins". Mol. Cell. Biol. UNITED STATES. 17 (2): 584–93. doi:10.1128/mcb.17.2.584. ISSN 0270-7306. PMC 231783. PMID 9001211.

Further reading

• Sagata N (1997). "What does Mos do in oocytes and somatic cells?". BioEssays. 19 (1): 13–21. doi:10.1002/bies.950190105. PMID 9008413. S2CID 1338222.
• Caubet JF, Mathieu-Mahul D, Bernheim A, et al. (1986). "Human proto-oncogene c-mos maps to 8q11". EMBO J. 4 (9): 2245–8. doi:10.1002/j.1460-2075.1985.tb03921.x. PMC 554492. PMID 3000766.
• Watson R, Oskarsson M, Vande Woude GF (1982). "Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus". Proc. Natl. Acad. Sci. U.S.A. 79 (13): 4078–82. Bibcode:1982PNAS...79.4078W. doi:10.1073/pnas.79.13.4078. PMC 346580. PMID 6287464.
• Heikinheimo O, Lanzendorf SE, Baka SG, Gibbons WE (1995). "Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos". Hum. Reprod. 10 (3): 699–707. doi:10.1093/oxfordjournals.humrep.a136019. PMID 7540181.
• Lenormand JL, Benayoun B, Guillier M, et al. (1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins". Mol. Cell. Biol. 17 (2): 584–93. doi:10.1128/mcb.17.2.584. PMC 231783. PMID 9001211.
• Liu H, Vuyyuru VB, Pham CD, et al. (1999). "Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association". Oncogene. 18 (23): 3461–70. doi:10.1038/sj.onc.1202699. PMID 10376524.
• Pham CD, Vuyyuru VB, Yang Y, et al. (1999). "Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos". Oncogene. 18 (30): 4287–94. doi:10.1038/sj.onc.1202804. PMID 10439036.
• Proikas-Cezanne T, Stabel S, Riethmacher D (2002). "Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos". BMC Biochem. 3: 6. doi:10.1186/1471-2091-3-6. PMC 102758. PMID 12022922.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kalejs M, Ivanov A, Plakhins G, et al. (2006). "Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe". BMC Cancer. 6: 6. doi:10.1186/1471-2407-6-6. PMC 1351196. PMID 16401344.