MORF4L1

Mortality factor 4-like protein 1 is a protein that in humans is encoded by the MORF4L1 gene.[5][6][7]

MORF4L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AQL, 2EFI, 2F5J, 2F5K, 2LKM, 2N1D
Identifiers
Aliases	MORF4L1, Eaf3, HsT17725, MEAF3, MORFRG15, MRG15, S863-6, FWP006, mortality factor 4 like 1
External IDs	OMIM: 607303 MGI: 1096551 HomoloGene: 86043 GeneCards: MORF4L1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.1 Start 78,810,487 bp[1] End 78,898,139 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.1 Start 90,091,665 bp[2] End 90,114,774 bp[2]
Gene ontology Molecular function • protein N-terminus binding • GO:0001948 protein binding • chromatin binding Cellular component • cell nucleus • nucleoplasm • nuclear speck • Sin3 complex • NuA4 histone acetyltransferase complex • histone acetyltransferase complex Biological process • chromatin remodeling • DNA recombination • chromatin silencing • regulation of transcription, DNA-templated • histone H2A acetylation • transcription, DNA-templated • cellular response to DNA damage stimulus • double-strand break repair via homologous recombination • histone H4 acetylation • regulation of growth • histone deacetylation • DNA repair • chromatin organization • cellular proliferation • histone acetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10933	21761
Ensembl	ENSG00000185787	ENSMUSG00000062270
UniProt	Q9UBU8	P60762
RefSeq (mRNA)	NM_206839 NM_001265603 NM_001265604 NM_001265605 NM_006791	NM_001039147 NM_024431 NM_001357780
RefSeq (protein)	NP_001252532 NP_001252533 NP_001252534 NP_006782 NP_996670	NP_001034236 NP_077751 NP_001344709
Location (UCSC)	Chr 15: 78.81 – 78.9 Mb	Chr 9: 90.09 – 90.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MORF4L1 has been shown to interact with MYST1,[8] Retinoblastoma protein[8][9] and MRFAP1.[8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000185787 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062270 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
6. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
7. "Entrez Gene: MORF4L1 mortality factor 4 like 1".
8. Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM (Dec 2002). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". The Journal of Biological Chemistry. 277 (52): 50860–6. doi:10.1074/jbc.M203839200. PMID 12397079.
9. Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM (Oct 2001). "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14". The Journal of Biological Chemistry. 276 (42): 39171–8. doi:10.1074/jbc.M103435200. PMID 11500496.

Further reading

• Doyon Y, Côté J (Apr 2004). "The highly conserved and multifunctional NuA4 HAT complex". Current Opinion in Genetics & Development. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
• Pena AN, Pereira-Smith OM (Apr 2007). "The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging". Annals of the New York Academy of Sciences. 1100 (1): 299–305. doi:10.1196/annals.1395.031. PMID 17460191.
• Bertram MJ, Bérubé NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM (Feb 1999). "Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes". Molecular and Cellular Biology. 19 (2): 1479–85. doi:10.1128/mcb.19.2.1479. PMC 116076. PMID 9891081.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM (Oct 2001). "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14". The Journal of Biological Chemistry. 276 (42): 39171–8. doi:10.1074/jbc.M103435200. PMID 11500496.
• Yochum GS, Ayer DE (Nov 2002). "Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Molecular and Cellular Biology. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
• Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM (Dec 2002). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". The Journal of Biological Chemistry. 277 (52): 50860–6. doi:10.1074/jbc.M203839200. PMID 12397079.
• Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". The Journal of Biological Chemistry. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
• Tominaga K, Leung JK, Rookard P, Echigo J, Smith JR, Pereira-Smith OM (Dec 2003). "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner". The Journal of Biological Chemistry. 278 (49): 49618–24. doi:10.1074/jbc.M309192200. PMID 14506250.
• Doyon Y, Selleck W, Lane WS, Tan S, Côté J (Mar 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Molecular and Cellular Biology. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
• Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM (Oct 2004). "PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice". Molecular and Cellular Biology. 24 (19): 8366–73. doi:10.1128/MCB.24.19.8366-8373.2004. PMC 516751. PMID 15367658.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (Nov 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Cai Y, Jin J, Florens L, Swanson SK, Kusch T, Li B, Workman JL, Washburn MP, Conaway RC, Conaway JW (Apr 2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". The Journal of Biological Chemistry. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.