MKL2

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.[5][6]

MRTFB
Identifiers
Aliases	MRTFB, MRTF-B, NPD001, MKL1/myocardin like 2, myocardin related transcription factor B, MKL2
External IDs	OMIM: 609463 MGI: 3050795 HomoloGene: 40917 GeneCards: MRTFB
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.12 Start 14,071,321 bp[1] End 14,266,773 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 13,256,481 bp[2] End 13,417,529 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • GO:0001948 protein binding • cadherin binding Cellular component • cell nucleus Biological process • multicellular organism development • muscle organ development • regulation of transcription, DNA-templated • smooth muscle cell differentiation • positive regulation of striated muscle tissue development • positive regulation of transcription from RNA polymerase II promoter • cell differentiation • transcription, DNA-templated • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57496	239719
Ensembl	ENSG00000186260	ENSMUSG00000009569
UniProt	Q9ULH7	P59759
RefSeq (mRNA)	NM_001308142 NM_014048	NM_001122667 NM_153588 NM_181860
RefSeq (protein)	NP_001295071 NP_054767 NP_001352340 NP_001352341 NP_001352342 NP_001352343 NP_001352344 NP_001352345 NP_001352346 NP_001352347 NP_001352348 NP_001352349 NP_001352350	NP_001116139 NP_705816 NP_862908
Location (UCSC)	Chr 16: 14.07 – 14.27 Mb	Chr 16: 13.26 – 13.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation and motile function. [7]

References

1. GRCh38: Ensembl release 89: ENSG00000186260 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009569 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
6. "Entrez Gene: MKL2 MKL/myocardin-like 2".
7. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (September 2016). "Emerging roles of the myocardin family of proteins in lipid and glucose metabolism". J Physiol. 594 (17): 4741–4752. doi:10.1113/JP271913. PMC 5009794. PMID 27060572.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Wang DZ, Li S, Hockemeyer D, et al. (2003). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14855–60. doi:10.1073/pnas.222561499. PMC 137508. PMID 12397177.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cen B, Selvaraj A, Burgess RC, et al. (2003). "Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes". Mol. Cell. Biol. 23 (18): 6597–608. doi:10.1128/MCB.23.18.6597-6608.2003. PMC 193697. PMID 12944485.
• Selvaraj A, Prywes R (2004). "Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation". J. Biol. Chem. 278 (43): 41977–87. doi:10.1074/jbc.M305679200. PMID 14565952.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Morita T, Mayanagi T, Sobue K (2007). "Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling". J. Cell Biol. 179 (5): 1027–42. doi:10.1083/jcb.200708174. PMC 2099179. PMID 18056415.