MINK1

Misshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.[5][6][7]

MINK1
Identifiers
Aliases	MINK1, B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta, misshapen like kinase 1
External IDs	OMIM: 609426 MGI: 1355329 HomoloGene: 56762 GeneCards: MINK1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,833,340 bp[1] End 4,898,061 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 70,562,881 bp[2] End 70,614,483 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • kinase activity • protein serine/threonine kinase activity • GO:0001948 protein binding • ATP binding • MAP kinase kinase kinase kinase activity Cellular component • cytoplasm • cytosol • postsynaptic membrane • Golgi apparatus • cell projection • GO:0097483, GO:0097481 postsynaptic density • membrane • cell membrane • synapse • cell junction • axon • dendrite • extracellular exosome Biological process • actin cytoskeleton reorganization • regulation of cell migration • GO:0007243 intracellular signal transduction • microvillus assembly • dendrite morphogenesis • phosphorylation • response to stress • positive regulation of JNK cascade • regulation of cell-matrix adhesion • regulation of AMPA receptor activity • multicellular organism development • protein phosphorylation • JNK cascade • regulation of cell-cell adhesion • autophosphorylation • chemical synaptic transmission • activation of MAPKKK activity • regulation of mitotic cell cycle • regulation of apoptotic process • neuron projection morphogenesis • MAPK cascade • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • positive regulation of p38MAPK cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50488	50932
Ensembl	ENSG00000141503	ENSMUSG00000020827
UniProt	Q8N4C8	Q9JM52
RefSeq (mRNA)	NM_001024937 NM_015716 NM_153827 NM_170663 NM_001321236	NM_001045959 NM_001045964 NM_016713 NM_176893
RefSeq (protein)	NP_001020108 NP_001308165 NP_056531 NP_722549 NP_733763	NP_001039424 NP_001039429 NP_057922 NP_795712
Location (UCSC)	Chr 17: 4.83 – 4.9 Mb	Chr 11: 70.56 – 70.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.[7]

Interactions

MINK1 has been shown to interact with NCK1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000141503 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020827 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dan I, Watanabe NM, Kobayashi T, Yamashita-Suzuki K, Fukagaya Y, Kajikawa E, Kimura WK, Nakashima TM, Matsumoto K, Ninomiya-Tsuji J, Kusumi A (Mar 2000). "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development". FEBS Letters. 469 (1): 19–23. doi:10.1016/S0014-5793(00)01247-3. PMID 10708748. S2CID 39793431.
6. Dan I, Watanabe NM, Kajikawa E, Ishida T, Pandey A, Kusumi A (Jul 2002). "Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution". Nucleic Acids Research. 30 (13): 2906–10. doi:10.1093/nar/gkf407. PMC 117062. PMID 12087176.
7. "Entrez Gene: MINK1 misshapen-like kinase 1 (zebrafish)".
8. Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X (Dec 2004). "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta". The Journal of Biological Chemistry. 279 (52): 54387–97. doi:10.1074/jbc.M404497200. PMID 15469942.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Campdelacreu J, Ezquerra M, Muñoz E, Oliva R, Tolosa E (Apr 2003). "Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy". Neuroscience Letters. 340 (2): 158–60. doi:10.1016/S0304-3940(03)00105-8. PMID 12668260. S2CID 45355312.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X (Dec 2004). "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta". The Journal of Biological Chemistry. 279 (52): 54387–97. doi:10.1074/jbc.M404497200. PMID 15469942.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.