MARCH7

E3 ubiquitin-protein ligase MARCH7 is an enzyme that in humans is encoded by the MARCH7 gene.[4][5]

MARCHF7
Identifiers
Aliases	MARCHF7, AXO, AXOT, MARCH-VII, RNF177, membrane associated ring-CH-type finger 7, MARCH7
External IDs	OMIM: 613334 MGI: 1931053 HomoloGene: 10753 GeneCards: MARCHF7
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.2 Start 159,712,457 bp[1] End 159,771,027 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • metal ion binding • transferase activity • enzyme binding • ubiquitin conjugating enzyme binding • ubiquitin binding • MDM2/MDM4 family protein binding • GO:0001948 protein binding Cellular component • cell nucleus • cytosol • cell membrane Biological process • negative regulation of T cell proliferation • regulation of tolerance induction • protein ubiquitination • positive regulation of cell proliferation • negative regulation of DNA damage response, signal transduction by p53 class mediator • protein stabilization • protein autoubiquitination • negative regulation of proteasomal protein catabolic process • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation of protein polyubiquitination • negative regulation of protein autoubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64844	57438
Ensembl	ENSG00000136536	n/a
UniProt	Q9H992	Q9WV66
RefSeq (mRNA)	NM_001282805 NM_001282806 NM_001282807 NM_022826	NM_020575
RefSeq (protein)	NP_001269734 NP_001269735 NP_001269736 NP_073737 NP_001363163 NP_001363164 NP_001363165 NP_001363166 NP_001363167 NP_001363168 NP_001363169 NP_001363170 NP_001363171 NP_001363172 NP_001363173 NP_001363174 NP_001363175 NP_001363176 NP_001363177 NP_001363178 NP_001363179 NP_001363180 NP_001363181 NP_001363182 NP_001363183 NP_001363184	NP_065600
Location (UCSC)	Chr 2: 159.71 – 159.77 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136536 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
5. "Entrez Gene: MARCH7 membrane-associated ring finger (C3HC4) 7".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Metcalfe SM, Muthukumarana PA, Thompson HL, et al. (2005). "Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance". FEBS Lett. 579 (3): 609–14. doi:10.1016/j.febslet.2004.12.027. PMID 15670816. S2CID 24334635.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Flierman D, Coleman CS, Pickart CM, et al. (2006). "E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11589–94. doi:10.1073/pnas.0605215103. PMC 1520313. PMID 16868077.
• Muthukumarana PA, Lyons GE, Miura Y, et al. (2007). "Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance". Int. Immunopharmacol. 6 (13–14): 1993–2001. doi:10.1016/j.intimp.2006.09.015. PMID 17161353.