MAP6

Microtubule-associated protein 6 (MAP6) or stable tubule-only polypeptide (STOP or STOP protein) is a protein that in humans is encoded by the MAP6 gene.[5][6]

MAP6
Identifiers
Aliases	MAP6, MTAP6, N-STOP, STOP, MAP6-N, microtubule associated protein 6
External IDs	OMIM: 601783 MGI: 1201690 HomoloGene: 7850 GeneCards: MAP6
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.5 Start 75,586,918 bp[1] End 75,669,120 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 99,267,447 bp[2] End 99,337,137 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • calmodulin binding • microtubule binding Cellular component • cytoplasm • perinuclear region of cytoplasm • Golgi apparatus • microtubules • cytoskeleton • membrane • axon • dendrite • transport vesicle membrane • cytoplasmic vesicle • cell projection • Golgi-associated vesicle • cis-Golgi network Biological process • lysosome localization • microtubule cytoskeleton organization • dendrite morphogenesis • cytoskeleton-dependent intracellular transport • positive regulation of axonogenesis • regulation of microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4135	17760
Ensembl	ENSG00000171533	ENSMUSG00000055407
UniProt	Q96JE9	Q7TSJ2
RefSeq (mRNA)	NM_033063 NM_207577	NM_001043355 NM_001048167 NM_010837
RefSeq (protein)	NP_149052 NP_997460	NP_001036820 NP_001041632 NP_034967
Location (UCSC)	Chr 11: 75.59 – 75.67 Mb	Chr 7: 99.27 – 99.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a microtubule-associated protein (MAP). The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000171533 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055407 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Andrieux A, Salin PA, Vernet M, Kujala P, Baratier J, Gory-Faure S, Bosc C, Pointu H, Proietto D, Schweitzer A, Denarier E, Klumperman J, Job D (Sep 2002). "The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders". Genes Dev. 16 (18): 2350–64. doi:10.1101/gad.223302. PMC 187434. PMID 12231625.
6. "Entrez Gene: MAP6 microtubule-associated protein 6".

Further reading

• Bosc C, Cronk JD, Pirollet F, et al. (1996). "Cloning, expression, and properties of the microtubule-stabilizing protein STOP". Proc. Natl. Acad. Sci. U.S.A. 93 (5): 2125–30. doi:10.1073/pnas.93.5.2125. PMC 39921. PMID 8700896.
• Denarier E, Aguezzoul M, Jolly C, et al. (1998). "Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6)". Biochem. Biophys. Res. Commun. 243 (3): 791–6. doi:10.1006/bbrc.1998.8179. PMID 9501006.
• Zapata JM, Pawlowski K, Haas E, et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". J. Biol. Chem. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bosc C, Andrieux A, Job D (2003). "STOP proteins". Biochemistry. 42 (42): 12125–32. doi:10.1021/bi0352163. PMID 14567673.
• Letournel F, Bocquet A, Dubas F, et al. (2004). "Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis". J. Neuropathol. Exp. Neurol. 62 (12): 1211–9. doi:10.1093/jnen/62.12.1211. PMID 14692697. S2CID 17038868.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

• Cuveillier C, Denarier E, Andrieux A, Delphin C (2020). "MAP6 is an intraluminal protein that induces neuronal microtubules to coil". Sci. Adv. 6 (14): eaaz4344. doi:10.1126/sciadv.aaz4344. PMC 7112752. PMID 32270043.