Liu Xu (chemist)

Liu Xu (Chinese: 刘旭; 29 September 1938 – 5 September 2019)[1] was a Chinese pharmaceutical chemist known for the discovery of artesunate,[2][3] a novel antimalarial drug.[4] The discovery of artesunate solves the problem that artemisinin is nearly insoluble in water. Artesunate can be given by intravenous injection, intramuscular injection, by mouth, and by rectum.[5]

In this Chinese name, the family name is Liu.
Liu Xu
刘旭
Born(1938-09-29)29 September 1938
Rudong, Jiangsu, China
DiedSeptember 5, 2019(2019-09-05) (aged 80)
Guilin, China
CitizenshipChinese
Alma materChina Pharmaceutical University
Known forDiscovering Artesunate
AwardsState Award for Inventions (1989)
China Patent Award (1991)
State Science and Technology Progress Award (2002)
Scientific career
FieldsMedicinal chemistry
Antimalarial medication
Clinical research
InstitutionsGuilin Pharmaceutical Co., Ltd

For his work, Liu received the 1989 state award for inventions and the 2002 State Science and Technology Progress Award.

Early life

Liu Xu was born in Rudong, Jiangsu, China, on 29 December 1938. Xu Liu studied at the Department of Pharmacy in China Pharmaceutical University and graduated in 1959. From August 1959 to 1961, Liu Xu took part in the project of synthesizing new varieties of sulfa drugs in the Beijing Institute of Pharmaceutical Industry. In 1961, he moved to Guilin Pharmaceutica due to the Third-Front Movement.

Research career

On May 21st, 1977, the Office of Project 523 gave Guilin Pharmaceutica the task of revising the structure of artemisinin in order to improve the drug's effect and solve the water solubility problem. Liu Xu was appointed to be the leader of this project. Liu created a series of derivatives and finally found Derivative No 804, later named as artesunate, which has 3 to 7 times more efficacy in malaria treatment than artemisinin and can be manufactured into water-soluble preparations. It is possible to use artesunate for intravenous injection, so it can be used to treat severe malaria.

On Oct 4th 1981, in the Malaria Chemotherapy Seminar held by WHO, artesunate was chosen as a priority development project.

The artesunate project won the third prize of the National Invention Award in 1989. On 1988 Oct 29th artesunate obtained patent authorization from China Patent Office.

In 1996 Zhou Guangzhao, dean of CAS at that time, released a reward list for artemisinin research results, including 10 scientists who made major contributions to the project. Liu Xu’s name was on the list due to his role in the creation of artesunate.

Awards
  • 1989, State Award for Inventions (1st inventor)
  • 1991, China Patent Award
  • 1992, (One of the) Ten Science and Technology Achievements in China, State Science Commission, China
  • 2002, State Science and Technology Progress Award

References
  1. 青蒿琥酯发明人刘旭逝世 他挽救了2400万重症疟疾患者
  2. Liu, Xu (1980). "Study on artemisinin derivatives". Chinese Pharmaceutical Journal. 1980 (15): 183.
  3. Li, Guoqiao author. Artemisinin-based and other antimalarials : detailed account of studies by Chinese scientists who discovered and developed them. ISBN 9780128132111. OCLC 1016908376.
  4. 桂林生活网—桂林日报 (2018-06-20). "桂林科学家刘旭：书写人类抗疟事业传奇". Retrieved 2019-03-05.
  5. Rosenthal, Philip J. (24 April 2008). "Artesunate for the Treatment of Severe Falciparum Malaria". New England Journal of Medicine. 358 (17): 1829–1836. doi:10.1056/NEJMct0709050. PMID 18434652.
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