Liu Wei Di Huang Wan

Liu Wei Di Huang Wan, also known as Liuwei Dihuang teapills (simplified Chinese: 六味地黄丸; traditional Chinese: 六味地黃丸; pinyin: liùwèi dìhuáng wán) or Six Flavor Rehmanni, is a prescription (方剂 fāng jì) in traditional Chinese medicine and pharmacy to treat yin deficiency. In Japanese kampo, it is known as "Rokumi-gan" (六味丸 ろくみがん) (it is also known as Kampo #87). It is commonly made into Chinese patent medicine.

History

The formula was created by Qian Yi as dihuang pill (地黄丸). It was published in "Xiao'er Yao Zheng Zhi Jue" (also known as "Key to Therapeutics of Children's Diseases" or "The Correct Execution of Pediatric Medicinals and Patterns" simplified Chinese: 小儿药证直诀; traditional Chinese: 小兒藥證直訣; pinyin: Xiǎo'ér Yào Zhèng Zhí Jué) in 1119 by Qian Yi's student.[1]

The formula was altered slightly when it was borrowed as a Japanese kampo formula. Some Chinese species of herbs were replaced with herbs found in Japan. For example, Alisma plantago-aquatica was replaced with Alisma orientale for zé xiè.

Derivatives

The Liuwei Dihuang Wan is one of the most important Chinese patent medicines, and is widely used in eastern Asia.[2] In China, there are hundreds of medicinal manufacturers who produce Liuwei Dihuang Wan and its derivatives. These derivatives include Zhibai Dihuang Wan, Guifu Dihuang Wan, Mingmu Dihuang Wan, Qiju Dihuang Wan, Maiwei Dihuang Wan, and Guishao Dihuang Wan.

Chinese classic herbal formula
Name Common Name Pinyin Chinese (T) Chinese (S) Katakana Kanji Genus species Action in this formula
Rehmanniae Radix Chinese foxglove root shú dì huáng 熟地黃 熟地黄 ジオウ 地黄 Rehmannia glutinosa Nourishes kidney yin & essence
Corni Fructus[3] Japanese cornel fruit shān zhū yú 山茱萸 山茱萸 サンシュユ 山茱萸 Cornus officinalis Nourishes the liver & kidney, restrains the leakage of the essence
Dioscoreae Rhizoma Chinese yam rhizome shān yào 山藥 山药 サンヤク 山薬 Dioscorea polystachya Tonifies spleen yin & consolidate the essence
Alismatis Rhizoma water plantain rhizome zé xiè 澤瀉 泽泻 タクシャ 沢瀉 Alisma plantago-aquatica Promotes urination to prevent buildup of significant fluids
Poria tuckahoe mushroom fú líng 茯苓 茯苓 ブクリョウ 茯苓 Poria cocos Bland: drains dampness from the spleen
Cortex Moutan Radicis Cortex]] tree peony bark mǔ dān pí 牡丹皮 牡丹皮 ボタンピ 牡丹皮 Cortex Moutan Radicis Clear liver fire

Japanese kampo formula
Name Common name Pinyin Chinese (T) Chinese (S) Katakana Kanji Genus species Grams %
Rehmanniae Radix Chinese foxglove root shú dì huáng 熟地黃 熟地黄 ジオウ 地黄 Rehmannia glutinosa 5.0 25%
Corni Fructus Japanese cornel fruit shān zhū yú 山茱萸 山茱萸 サンシュユ 山茱萸 Cornus officinalis 3.0 15%
Dioscoreae Rhizoma Japanese yam rhizome shān yào 山藥 山药 サンヤク 山薬 Dioscorea japonica 3.0 15%
Alismatis Rhizoma water plantain rhizome zé xiè 澤瀉 泽泻 タクシャ 沢瀉 Alisma orientale 3.0 15%
Poria tuckahoe mushroom fú líng 茯苓 茯苓 ブクリョウ 茯苓 Poria cocos 3.0 15%
Paeoniae suffruticosa Cortex tree peony bark mǔ dān pí 牡丹皮 牡丹皮 ボタンピ 牡丹皮 Paeonia suffruticosa 3.0 15%

See also

References
  1. "Archived copy". Archived from the original on 2004-01-21. Retrieved 2007-02-05.CS1 maint: archived copy as title (link)
  2. Xinfeng Zhao, Yue Wang, Yuqing Sun. "Simultaneous determination of four bioactive constituents in Liuwei Dihuang Pills by micellar electrokinetic chromatography", Journal of Pharmaceutical and Biomedical Analysis, Volume 44, Issue 5, 3 September 2007, Pages 1183-1186.
  3. Huahong Wang, Zhezhi Wang, Wubao Guo. "Comparative determination of ursolic acid and oleanolic acid of Macrocarpium officinalis (Sieb. et Zucc.) Nakai by RP-HPLC", Industrial Crops and Products, Volume 28, Issue 3, November 2008, Pages 328-332.
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