Leucine carboxyl methyltransferase 1

Leucine carboxyl methyltransferase 1 is an enzyme that in humans is encoded by the LCMT1 gene.[5][6]

LCMT1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3IEI, 3O7W, 3P71
Identifiers
Aliases	LCMT1, LCMT, PPMT1, CGI-68, leucine carboxyl methyltransferase 1
External IDs	OMIM: 610286 MGI: 1353593 HomoloGene: 41123 GeneCards: LCMT1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 25,111,731 bp[1] End 25,178,231 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 123,369,784 bp[2] End 123,430,358 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • protein methyltransferase activity • S-adenosylmethionine-dependent methyltransferase activity • transferase activity • GO:0001948 protein binding • protein C-terminal carboxyl O-methyltransferase activity • protein C-terminal leucine carboxyl O-methyltransferase activity Cellular component • cytosol • nucleoplasm Biological process • regulation of mitotic cell cycle spindle assembly checkpoint • methylation • C-terminal protein methylation • regulation of glucose metabolic process • regulation of apoptotic process • negative regulation of protein complex assembly • cellular protein modification process • protein methylation • G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51451	30949
Ensembl	ENSG00000205629	ENSMUSG00000030763
UniProt	Q9UIC8	n/a
RefSeq (mRNA)	NM_001032391 NM_016309	NM_025304 NM_001355050
RefSeq (protein)	NP_001027563 NP_057393	n/a
Location (UCSC)	Chr 16: 25.11 – 25.18 Mb	Chr 7: 123.37 – 123.43 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

LCMT1 has been shown to interact with FXR2.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000205629 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030763 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
6. "Entrez Gene: LCMT1 leucine carboxyl methyltransferase 1".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

• Lee JA, Pallas DC (Oct 2007). "Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells". The Journal of Biological Chemistry. 282 (42): 30974–84. doi:10.1074/jbc.M704861200. PMC 3516869. PMID 17724024.
• De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J (Dec 1999). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry. 38 (50): 16539–47. doi:10.1021/bi991646a. PMID 10600115.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.