Left-right determination factor 1

Left-right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene. [5]

LEFTY1
Identifiers
Aliases	LEFTY1, LEFTB, LEFTYB, left-right determination factor 1
External IDs	OMIM: 603037 MGI: 107405 HomoloGene: 49231 GeneCards: LEFTY1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.12 Start 225,886,282 bp[1] End 225,911,382 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 180,935,022 bp[2] End 180,938,400 bp[2]
Gene ontology Molecular function • transforming growth factor beta receptor binding • cytokine activity • growth factor activity Cellular component • extracellular region • extracellular Biological process • regulation of apoptotic process • multicellular organism development • positive regulation of pathway-restricted SMAD protein phosphorylation • heart morphogenesis • determination of left/right symmetry • negative regulation of transcription from RNA polymerase II promoter • transforming growth factor beta receptor signaling pathway • regulation of MAPK cascade • SMAD protein signal transduction • cell development • BMP signaling pathway • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10637	13590
Ensembl	ENSG00000243709	ENSMUSG00000038793
UniProt	O75610	Q64280
RefSeq (mRNA)	NM_020997	NM_010094
RefSeq (protein)	NP_066277	NP_034224
Location (UCSC)	Chr 1: 225.89 – 225.91 Mb	Chr 1: 180.94 – 180.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

References

1. GRCh38: Ensembl release 89: ENSG00000243709 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038793 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Left-right determination factor 1". Retrieved 2016-08-03.

Further reading

• Besser D (2004). "Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3". J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.