LIMD1

LIM domain-containing protein 1 is a protein that in humans is encoded by the LIMD1 gene.[5][6]

LIMD1
Identifiers
Aliases	LIMD1, LIM domains containing 1
External IDs	OMIM: 604543 MGI: 1352502 HomoloGene: 8478 GeneCards: LIMD1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 45,555,394 bp[1] End 45,686,341 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F4|9 74.0 cM Start 123,478,706 bp[2] End 123,521,552 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • GO:0001948 protein binding • GO:0001106 transcription corepressor activity • zinc ion binding Cellular component • cytoplasm • RISC complex • focal adhesion • adherens junction • P-body • cell junction • cell nucleus • transcription regulator complex • cytosol • cell membrane • intercellular junction Biological process • response to hypoxia • regulation of transcription, DNA-templated • phosphorylation • negative regulation of osteoblast differentiation • transcription, DNA-templated • positive regulation of gene silencing by miRNA • multicellular organism development • negative regulation of hippo signaling • gene silencing by miRNA • cytoskeleton organization • cytoplasmic mRNA processing body assembly • regulation of cell shape • osteoblast development • gene silencing by RNA • negative regulation of transcription, DNA-templated • cell migration • negative regulation of canonical Wnt signaling pathway • signal transduction • regulation of transcription from RNA polymerase II promoter in response to hypoxia Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8994	29806
Ensembl	ENSG00000144791	ENSMUSG00000025239
UniProt	Q9UGP4	Q9QXD8
RefSeq (mRNA)	NM_014240	NM_013860
RefSeq (protein)	NP_055055	NP_038888
Location (UCSC)	Chr 3: 45.56 – 45.69 Mb	Chr 9: 123.48 – 123.52 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000144791 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025239 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kiss H, Kedra D, Yang Y, Kost-Alimova M, Kiss C, O'Brien KP, Fransson I, Klein G, Imreh S, Dumanski JP (Feb 2000). "A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3". Hum Genet. 105 (6): 552–9. doi:10.1007/s004390051144. PMID 10647888.
6. "Entrez Gene: LIMD1 LIM domains containing 1".

Further reading

• Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P." Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–5. doi:10.1073/pnas.021561498. PMC 14685. PMID 11158571.
• Kiss H, Kedra D, Kiss C, et al. (2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics. 73 (1): 10–9. doi:10.1006/geno.2000.6498. PMID 11352561.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sharp TV, Munoz F, Bourboulia D, et al. (2004). "LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16531–6. doi:10.1073/pnas.0407123101. PMC 534532. PMID 15542589.
• Feng Y, Longmore GD (2005). "The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex". Mol. Cell. Biol. 25 (10): 4010–22. doi:10.1128/MCB.25.10.4010-4022.2005. PMC 1087715. PMID 15870274.
• Huggins CJ, Gill M, Andrulis IL (2007). "Identification of rare variants in the hLIMD1 gene in breast cancer". Cancer Genet. Cytogenet. 178 (1): 36–41. doi:10.1016/j.cancergencyto.2007.06.007. PMID 17889706.