LEO1

RNA polymerase-associated protein LEO1 is an enzyme that in humans is encoded by the LEO1 gene.[5][6]

LEO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M6T
Identifiers
Aliases	LEO1, RDL, LEO1 homolog, Paf1/RNA polymerase II complex component
External IDs	OMIM: 610507 MGI: 2685031 HomoloGene: 133895 GeneCards: LEO1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 51,938,025 bp[1] End 51,971,778 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 D Start 75,441,524 bp[2] End 75,466,432 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA polymerase II C-terminal domain phosphoserine binding • GO:0001948 protein binding Cellular component • cell nucleus • centrosome • Cdc73/Paf1 complex • nucleoplasm • fibrillar center Biological process • negative regulation of myeloid cell differentiation • positive regulation of mRNA 3'-end processing • mRNA polyadenylation • endodermal cell fate commitment • Wnt signaling pathway • histone H2B ubiquitination • stem cell population maintenance • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • histone monoubiquitination • positive regulation of transcription elongation from RNA polymerase II promoter • histone modification • beta-catenin-TCF complex assembly • transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • protein ubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	123169	235497
Ensembl	ENSG00000166477	ENSMUSG00000042487
UniProt	Q8WVC0	Q5XJE5
RefSeq (mRNA)	NM_001286430 NM_138792 NM_001323903 NM_001323904	NM_001006122 NM_001039522
RefSeq (protein)	NP_001273359 NP_001310832 NP_001310833 NP_620147	NP_001034611
Location (UCSC)	Chr 15: 51.94 – 51.97 Mb	Chr 9: 75.44 – 75.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000166477 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042487 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rozenblatt-Rosen O, Hughes CM, Nannepaga SJ, Shanmugam KS, Copeland TD, Guszczynski T, Resau JH, Meyerson M (Jan 2005). "The Parafibromin Tumor Suppressor Protein Is Part of a Human Paf1 Complex". Mol Cell Biol. 25 (2): 612–20. doi:10.1128/MCB.25.2.612-620.2005. PMC 543415. PMID 15632063.
6. "Entrez Gene: LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhao L, Tong T, Zhang Z (2005). "Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts". FASEB J. 19 (6): 521–32. doi:10.1096/fj.04-2689com. PMID 15791002.
• Mosimann C, Hausmann G, Basler K (2006). "Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo". Cell. 125 (2): 327–41. doi:10.1016/j.cell.2006.01.053. PMID 16630820.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.