Kristi Kiick

Kristi Lynn Kiick is the Blue and Gold Distinguished Professor of Materials Science and Engineering at the University of Delaware.[2] She studies polymers, biomaterials and hydrogels for drug delivery and regenerative medicine. She is a Fellow of the American Chemical Society, the American Institute for Medical and Biological Engineering, and of the National Academy of Inventors. She served for nearly eight years as the Deputy Dean of the College of Engineering at the University of Delaware.

Kristi Kiick
Kristi Kiick at the University of York in January 2020
Born
Kristi Lynn Kiick

1967 (age 53–54)[1]
Alma materUniversity of Delaware (BSc)
University of Georgia (MSc)
University of Massachusetts Amherst (MSc, PhD)
AwardsNational Science Foundation CAREER Award (2003)
Fulbright Scholar (2019)
Scientific career
FieldsBiomaterials[2]
InstitutionsUniversity of Delaware
ThesisExpanding the scope of templated macromolecular synthesis in vivo: The incorporation of methionine analogues into proteins in vivo by altering the methionyl-tRNA synthetase activity of a bacterial expression host (2001)
Doctoral advisorDavid A. Tirrell
InfluencesCarolyn R. Bertozzi
Websitesites.udel.edu/kiickgroup

Early life and education

Kiick first became interested in a career in the chemical sciences when she was at high school.[3] She studied chemistry at the University of Delaware, from which she graduated summa cum laude as a Eugene du Pont memorial distinguished scholar.[4] She was a Master's student at the University of Georgia, where she was awarded a National Science Foundation (NSF) predoctoral fellowship, and joined Kimberly-Clark as a research scientist in 1992.[4] Kiick returned to academia for a second Master's degree in polymer science and engineering at the University of Massachusetts Amherst.[4] She completed her doctoral research at the California Institute of Technology, as a National Defense Science and Engineering Graduate (NDSEG) fellow.[4] She completed her PhD from the University of Massachusetts Amherst on templated macromolecular synthesis in 2001 under the supervision of David A. Tirrell,[5] prior to starting her faculty position at the University of Delaware in 2001.

Research and career

Kiick designs polymer nanostructures for targeted therapies and hydrogel matrices for regenerative medicine.[6] She makes use of biomimetic self-assembly, bioconjugation and biosynthesis.[7] In particular, Kiick has worked on polymer-peptide macromolecular structures that can engage cellular targets. These include the use of polyethylene glycol (PEG) in click chemistry to form hydrogels that degrade selectively in response to molecules present in tissues and extracellular matrix.[7] Kiick has shown it is possible to selectively release small molecule cargo with a tuned release for applications in targeted drug-delivery and vascular grafts.[7] She has developed resilin-like polypeptides (RLP), elastomeric materials that can be cross-linked using small molecules, as well as hydrogels that contain nanoparticles for targeting tumors and inflammatory conditions.[6] Resilin is a primary elastomeric protein that is found in insects, and helps them to jump long distances and produce sound.[8]

She joined the faculty at the University of Delaware in 2001, and earned the rank of Associate Professor in 2007. In 2011 Kiick was promoted to the rank of Professor of Materials Science and Engineering and also named Deputy Dean of the University of Delaware’s College of Engineering.[9] In 2019-2020 she was awarded a Leverhulme Visiting Professorship from the Leverhulme Trust and a Fulbright Scholarship from the Fulbright Program to the University of Nottingham, to develop protocols for fabricating bioelastomeric materials.[10][11]

Awards and honours

Her awards and honours include:

Selected publications

Her publications include:

  • Kiick, K. L.; Saxon, E.; Tirrell, D. A.; Bertozzi, C. R. (2002-01-08). "Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation". Proceedings of the National Academy of Sciences. 99 (1): 19–24. Bibcode:2002PNAS...99...19K. doi:10.1073/pnas.012583299. ISSN 0027-8424. PMC 117506. PMID 11752401.
  • Kharkar, Prathamesh M.; Kiick, Kristi L.; Kloxin, April M. (2013-08-05). "Designing degradable hydrogels for orthogonal control of cell microenvironments". Chemical Society Reviews. 42 (17): 7335–7372. doi:10.1039/C3CS60040H. ISSN 1460-4744. PMC 3762890. PMID 23609001.
  • Baldwin, Aaron D.; Kiick, Kristi L. (2011-10-19). "Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments". Bioconjugate Chemistry. 22 (10): 1946–1953. doi:10.1021/bc200148v. ISSN 1043-1802. PMC 3220410. PMID 21863904.

Personal life

Kiick is married with two children.[3]

References
  1. Kristi Kiick at Library of Congress Authorities
  2. Kristi Kiick publications indexed by Google Scholar
  3. "Author of the Week: Prof. Kristi L. Kiick – Polymer Chemistry Blog". Retrieved 2020-01-22.
  4. "Kristi Kiick honored for inventions | UDaily". udel.edu. Retrieved 2020-01-22.
  5. Kiick, Kristi Lynn (2001). Expanding the scope of templated macromolecular synthesis in vivo: The incorporation of methionine analogues into proteins in vivo by altering the methionyl-tRNA synthetase activity of a bacterial expression host. umass.edu (PhD thesis). University of Massachusetts Amherst. OCLC 931602667.
  6. "Research | Kiick Research Group". Retrieved 2020-01-22.
  7. "Events: Institute of Bioengineering, Queen Mary University of London". bioengineering.qmul.ac.uk. Retrieved 2020-01-22.
  8. "Flexible Insect Protein Inspires Super Rubber". NPR.org. Retrieved 2020-01-22.
  9. "Kristi Kiick Kristi Kiick Named Deputy Dean of College of Engineering Effective Aug. 1". aimbe.org. Retrieved 2020-01-22.
  10. "2019-20 American Fulbright Scholar Award grantees | US-UK Fulbright Commission". fulbright.org.uk. Retrieved 2020-01-22.
  11. "International scholarship in materials | UDaily". udel.edu. Retrieved 2020-01-22.
  12. "Department of Chemistry". chem.umn.edu. Retrieved 2020-01-22.
  13. "Awards & Honors | Women's Caucus". Retrieved 2020-01-22.
  14. "POLY - What's New". old.polyacs.org. Retrieved 2020-01-22.
  15. "The Covestro Lecture Series | School of Polymer Science and Engineering | The University of Southern Mississippi". www.usm.edu. Retrieved 2020-01-22.
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