Kenneth B. Storey

Kenneth B. Storey FRSC (born October 23, 1949) is a Canadian scientist whose work draws from a variety of fields including biochemistry and molecular biology. He is a Professor of Biology, Biochemistry and Chemistry at Carleton University in Ottawa, Canada. Storey has a world-wide reputation for his research on biochemical adaptation - the molecular mechanisms that allow animals to adapt to and endure severe environmental stresses such as deep cold, oxygen deprivation, and desiccation.[1]

Kenneth Storey

FRSC
Born
Kenneth Bruce Storey

(1949-10-23) October 23, 1949
Taber, Alberta, Canada
CitizenshipCanadian
AwardsRoyal Society of Canada Fellow (1990)
Flavelle Medal (2010)
Fry Medal (2011)
Cryo-Fellow (2012)
Scientific career
FieldsMolecular Physiology
Biochemistry
Biochemical Adaptation
InstitutionsCarleton University, Canada
Doctoral advisorPeter Hochachka

Biography

Kenneth Storey studied biochemistry at the University of Calgary (B.Sc. '71) and zoology at the University of British Columbia (Ph.D. '74).[2][3] Storey is a Professor of Biochemistry, cross-appointed in the Departments of Biology, Chemistry and Neuroscience and holds the Canada Research Chair in Molecular Physiology at Carleton University in Ottawa, Canada.[4]

Storey is an elected fellow of the Royal Society of Canada,[5] of the Society for Cryobiology[6] and of the American Association for the Advancement of Science. He has won fellowships and awards for research excellence including the Fry medal from the Canadian Society of Zoologists (2011), the Flavelle medal from the Royal Society of Canada (2010), Ottawa Life Sciences Council Basic Research Award (1998), a Killam Senior Research Fellowship (1993–1995), the Ayerst Award from the Canadian Society for Molecular Biosciences (1989), an E.W.R. Steacie Memorial Fellowship from the Natural Sciences and Engineering Research Council of Canada (1984–1986), and four Carleton University Research Achievement Awards. Storey is the author of over 844 research articles, the editor of seven books, has given over 500 talks at conferences and institutes worldwide, and organized numerous international symposia.[7]

Research

Storey is one of the most cited researchers in the world.[8] Storey's research includes studies of enzyme properties, gene expression, protein phosphorylation, and cellular signal transduction mechanisms to seek out the basic principles of how organisms endure and flourish under extreme conditions. He is particularly known within the field of cryobiology for his studies of animals that can survive freezing, especially the frozen "frog-sicles" (Rana sylvatica) that have made his work popular with multiple TV shows and magazines.[9][10][11] Storey's studies of the adaptations that allow frogs, insects, and other animals to survive freezing have made major advances in the understanding of how cells, tissues and organs can endure freezing.[11] Storey was also responsible for the discovery that some turtle species are freeze tolerant: newly hatched painted turtles that spend their first winter on land (Chrysemys picta marginata & C. p. bellii). These turtles are unique as they are the only reptiles, and highest vertebrate life form, known to tolerate prolonged natural freezing of extracellular body fluids during winter hibernation.[12] These advances may aid the development of organ cryopreservation technology.[4] A second area of his research is metabolic rate depression - understanding the mechanisms by which some animals can sharply reduce their metabolism and enter a state of hypometabolism or torpor that allows them to survive over the long term under difficult environmental stresses. His studies have identified molecular mechanisms that underlie metabolic arrest across phylogeny and that support phenomena including mammalian hibernation, estivation, and anoxia and ischemia tolerance. Control mechanisms include transcription factor changes that alter gene expression, and reversible phosphorylation of key metabolic enzymes by protein kinases and protein phosphatases. These studies across multiple species also hold key applications for medical science, particularly for preservation technologies that aim to extend the survival time of excised organs in cold or frozen storage.[4] Additional applications include insights into hyperglycemia in metabolic syndrome and diabetes,[13] and anoxic and ischemic damage caused by heart attack and stroke.[14] Furthermore, Storey's lab has created several web based programs freely available for data management, data plotting, and micro RNA analysis.


Selected recent publications

Books
  • Storey, K.B.; Tanino, K.K., eds. (2012). Temperature Adaptation in a Changing Climate. Wallingford: CABI Publishers. Archived from the original on 2012-04-10. Retrieved 2012-02-18.

Selected review articles

References
  1. "Kenneth Storey Bio". Ask the Scientists. PBS.
  2. "Ken Storey | the Storey Lab: Cell and Molecular Responses to Stress".
  3. "Kenneth B. Storey | Ph.D., Professor & Canada Research Chair | Carleton University, Ottawa | Institute of Biochemistry".
  4. "How research in Ottawa can preserve organs for transplant in the future" (PDF). Carleton University.
  5. "Royal Society of Canada members at Carleton University". Carleton University. Archived from the original on 2009-08-29.
  6. "Society for Cryobiology".
  7. "STOREY Lab".
  8. "Kenneth B. Storey | Ph.D., Professor & Canada Research Chair | Carleton University, Ottawa | Institute of Biochemistry".
  9. McIlroy, Anne (3 December 2009). "Frozen frogs thaw out and hop away". The Globe and Mail. Archived from the original on 22 August 2010. Retrieved 15 January 2010.
  10. "Melted Frogsicle". Discovery Channel. Archived from the original (Silverlight video) on 2008-07-01. Retrieved 2010-01-14.
  11. "Freeze and thaw frogs" (Silverlight video). Discovery Channel.
  12. Storey, KB; Storey, JM; Brooks, SP; Churchill, TA; Brooks, RJ (1988). "Hatchling turtles survive freezing during winter hibernation". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 8350–4. Bibcode:1988PNAS...85.8350S. doi:10.1073/pnas.85.21.8350. PMC 282428. PMID 3186730.
  13. "New Theory Places Origin of Diabetes in an Age of Icy Hardships | Ice Age DiabetesS".
  14. "Archived copy". Archived from the original on 2008-10-30. Retrieved 2010-01-21.CS1 maint: archived copy as title (link)
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