Karen Ashe

Karen K. Hsiao Ashe is a professor at the Department of Neurology and Neuroscience at the University of Minnesota, where she holds the Edmund Wallace and Anne Marie Tulloch Chairs in Neurology and Neuroscience. She is Director of the Neurobiology of Alzheimer's Disease Research Laboratory at the University, and her specific research interest is memory loss resulting from Alzheimer's disease, and preventive care for the disease.[1] Her research has included the development of a line of genetically engineered mice that develop symptoms similar to Alzheimer's, the discovery of abnormal proteins that disrupt brain activity in the early stages of the disease, and the possibility of reversing memory loss due to the disease.[2]

Ashe graduated from St. Paul Academy and Summit School before graduating from Harvard University. She went on to earn an MD from Harvard and subsequently completed her PhD at MIT. She joined the University of Minnesota in 1992. She has also studied at the University of California, San Francisco.

She was awarded the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 2005[3] and the Potamkin Prize in 2006, together with Karen Duff and Bradley Hyman.[4]

Selected publications
  • "A specific amyloid-beta protein assembly in the brain impairs memory " by Sylvain Lesné, Ming Teng Koh, Linda Kotilinek, Rakez Kayed, Charles G. Glabe, Austin Yang, Michela Gallagher and Karen H. Ashe Nature Volume: 440 Issue: 7082 Pages: 352–357, Mar 16 2006.
  • "Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease " by G. P. Lim, F. Yang, T. Chu, P. Chen, W. Beech, B. Teter, T. Tran, O. Ubeda, K. Hsiao Ashe, S. A. Frautschy, and G. M. Cole Journal of Neuroscience Volume: 20 Issue: 15 Pages: 5709-5714 : Aug 1 2000.
  • "Natural oligomers of the amyloid-protein specifically disrupt cognitive function" by J. Cleary, D. M. Walsh, J.J. Hofmeister, G.M. Shankar, M.A. Kuskowski, D.J. Selkoe, K.H. Ashe Nature Neuroscience Volume: 8 Issue: 1 Pages: 79-84 Published: Jan 2005.

References
  1. Bosta, Phil (April 2009), "Fantastic Four", Twin Cities Business, archived from the original on 2011-10-03, retrieved 2010-03-14.
  2. "University of Minnesota Academic Health Center". Archived from the original on 2010-06-10. Retrieved 2010-03-14.
  3. "MetLife Foundation Awards for Medical Research in Alzheimer's Disease" (PDF). Archived from the original (PDF) on 13 October 2018.
  4. "Karen Duff Receives Prestigious Prize for Alzheimer's Research". NYU Langone Medical Center. Retrieved 6 August 2014.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.