Kappapapillomavirus

Kappapapillomavirus is a genus of viruses, in the family Papillomaviridae.[1] Rabbits serve as natural hosts. There are currently only two species in this genus including the type species Kappapapillomavirus 2. Diseases associated with this genus include: cutaneous and mucosal lesions.[2][3]

Kappapapillomavirus
Virus classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Zurhausenvirales
Family: Papillomaviridae
Genus: Kappapapillomavirus
Type species
Kappapapillomavirus 2

Taxonomy

Group: dsDNA

[3]

Structure

Viruses in Kappapapillomavirus are non-enveloped, with icosahedral geometries, and T=7 symmetry. The diameter is around 52-55 nm. Genomes are circular, around 8kb in length. The genome codes for 6 proteins, and has 6, 8 open reading frames.[2]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
KappapapillomavirusIcosahedralT=7Non-envelopedCircularMonopartite

Life cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear envelope breakdown. Rabbits serve as the natural host. Transmission routes are contact.[2]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
KappapapillomavirusRabbitsEpithelial: mucous; epithelial: skinCell receptor endocytosisLysisNucleusNucleusContact

References
  1. Van Doorslaer, K; Chen, Z; Bernard, HU; Chan, PKS; DeSalle, R; Dillner, J; Forslund, O; Haga, T; McBride, AA; Villa, LL; Burk, RD; ICTV Report Consortium (August 2018). "ICTV Virus Taxonomy Profile: Papillomaviridae". The Journal of General Virology. 99 (8): 989–990. doi:10.1099/jgv.0.001105. PMC 6171710. PMID 29927370.
  2. "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. "ICTV Report Papillomaviridae".
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